Interferon alpha/beta receptor 2 (IFNAR2) is a 515-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P48551.
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The mean pLDDT of this model is 64.4 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 27% |
| 70 to 90 | Confident: backbone generally right | 14% |
| 50 to 70 | Low: treat with caution | 20% |
| Below 50 | Very low: often disordered regions | 39% |
What pLDDT means and how to read it
Together with IFNAR1, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (PubMed:10049744, PubMed:17517919, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579,…
Heterodimer with IFNAR1; forming the receptor for type I interferon (PubMed:10049744, PubMed:21854986, PubMed:24075985, PubMed:7665574, PubMed:8181059). Interacts with JAK1 (PubMed:7759950, PubMed:8181059). Interacts with the transcriptional factors STAT1 and STAT2 (PubMed:28165510, PubMed:9121453). Interacts with USP18; indirectly via STAT2, it negatively regulates the assembly of the ternary…
Cell membrane, Secreted
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3S9D | X-ray | 2.0 Å | B/D=37-232 |
| 3S8W | X-ray | 2.6 Å | A/B/C=131-232 |
| 3SE4 | X-ray | 3.5 Å | C=34-232 |
| 3SE3 | X-ray | 4.0 Å | C=34-232 |
| 1N6U | NMR | A=28-237 | |
| 1N6V | NMR | A=28-237 | |
| 2HYM | NMR | A=28-237 | |
| 2KZ1 | NMR | B=28-237 | |
| 2LAG | NMR | B=28-237 |
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