Plasminogen-binding group A streptococcal M-like protein PAM (pam) is a 388-residue protein from Streptococcus pyogenes. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49054.
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The mean pLDDT of this model is 78.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 51% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 11% |
| Below 50 | Very low: often disordered regions | 19% |
What pLDDT means and how to read it
Binds to human plasminogen (and plasmin) via its kringle repeats. Also binds to albumin, immunoglobulin G and fibrinogen. Could provide the bacteria with a mechanism for invasion, as streptococcal-bound plasmin could permit tissue penetration
Secreted, cell wall
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6OG4 | X-ray | 1.7 Å | C=76-150 |
| 2DOH | X-ray | 2.3 Å | C=85-113 |
| 1I5K | X-ray | 2.7 Å | C/D=85-114 |
| 2DOI | X-ray | 3.1 Å | B/C=85-113 |
| 8TVL | EM | 3.8 Å | A=30-385 |
| 6OKW | NMR | A=85-133 | |
| 6OKX | NMR | A=85-133 | |
| 6OKY | NMR | A=85-133 | |
| 6OQ9 | NMR | A=85-133 | |
| 6OQJ | NMR | B=85-133 | |
| 6OQK | NMR | B=85-133 |
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