Mitochondrial import receptor subunit TOM22 (TOM22) is a 152-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49334.
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The mean pLDDT of this model is 76.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 19% |
| Below 50 | Very low: often disordered regions | 15% |
What pLDDT means and how to read it
Central component of the TOM (translocase of outer membrane) receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM20 and TOM70 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore. Docks TOM20 and TOM70 for interaction with the general TOM40 import pore (GIP) complex. May regulate the TOM machinery organization, stability and channel gating
Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOM5, TOM6, TOM7, TOM20, TOM22, TOM40 and TOM70). Interacts with TOM20 and TOM70. Interacts with FCJ1
Mitochondrion outer membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9J99 | EM | 2.94 Å | B/J=1-152 |
| 6UCU | EM | 3.06 Å | B/J=1-152 |
| 8XKY | EM | 3.42 Å | B/G=1-152 |
| 8W5K | EM | 3.6 Å | B/J=1-152 |
| 8XKW | EM | 3.64 Å | B/G=1-152 |
| 8XKX | EM | 3.7 Å | B/G=1-152 |
| 6JNF | EM | 3.81 Å | C/H=1-152 |
| 6UCV | EM | 4.1 Å | B/J/b/j=1-152 |
| 8HCO | EM | 4.1 Å | B/J=1-152 |
| 8W5J | EM | 4.4 Å | B/J=1-152 |
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