Winged helix repair factor 1 (WHR1) is a 254-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P49842.
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The mean pLDDT of this model is 87.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER) (PubMed:38252411, PubMed:38890355, PubMed:39353615, PubMed:39547223, PubMed:39547228, PubMed:39547229). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions (PubMed:39547223, PubMed:39547228, PubMed:39547229). TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex (PubMed:39547228). WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair…
Monomer in solution (PubMed:38890355). Homodimer; when bound to DNA (PubMed:38252411). Component of a transcription-coupled nucleotide excision repair (TC-NER) complex composed of STK19, ERCC6, ERCC8, DDA1, DDB1, ELOF1 and UVSSA which assembles and interacts with the multiprotein RNA polymerase II complex when it stalls at DNA lesions (PubMed:39547223, PubMed:39547228, PubMed:39547229)
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8YCM | X-ray | 1.32 Å | A/B=31-254 |
| 7XRB | X-ray | 1.65 Å | A/B=25-254 |
| 9BZ0 | EM | 1.9 Å | f=1-254 |
| 9ER2 | EM | 3.3 Å | Q=1-254 |
| 9FD2 | EM | 3.4 Å | g=1-254 |
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