9FD2: Pol II-TC-NER-STK19 complex

Name: PDB 9FD2: Structure of Pol II-TC-NER-STK19 complex
Published: 2024-11-13
License: https://creativecommons.org/publicdomain/zero/1.0/
Keywords: transcription

Structure of Pol II-TC-NER-STK19 complex. Determined by electron microscopy at 3.4 Å resolution. Released 13 Nov 2024.

Method: Electron microscopy
Resolution: 3.4 Å
Organisms: Sus scrofa domesticus, Homo sapiens
Chains: 22
Atoms: 51,949
Mol. weight: 1058.54 kDa
Ligands: ZN, MG
Released: 13 Nov 2024

Explore 9FD2 in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

9FD2 contains 272 α-helices and 377 β-strands across 19 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain a: 4 helices, 33 β-strands

Element	Residues	Length	Sheet
α-helix	2-10	9
α-helix	15-28	14
β-strand	30-31	2	77
β-strand	38	1	78
β-strand	46-51	6	79
β-strand	58-63	6	79
β-strand	68-72	5	79
β-strand	84	1	78
β-strand	86-90	5	79
β-strand	102-107	6	80
α-helix	108	1
β-strand	114-119	6	80
β-strand	123-128	6	80
β-strand	133-139	7	80
β-strand	144-149	6	81
β-strand	158-163	6	81
β-strand	168-172	5	81
β-strand	180-182	3	81
β-strand	189-194	6	82
β-strand	201-206	6	82
β-strand	210-215	6	82
β-strand	224-225	2	82
β-strand	248	1	83
β-strand	252-253	2	84
β-strand	259-263	5	84
β-strand	264	1	83
β-strand	269-273	5	84
β-strand	279	1	84
α-helix	294-296	3
β-strand	298-299	2	85
β-strand	307-312	6	85
β-strand	315-320	6	85
β-strand	326-330	5	85
β-strand	337-343	7	86
β-strand	348-353	6	86
β-strand	358-361	4	86
β-strand	362-363	2	77

Chain A: 76 helices, 70 β-strands

Element	Residues	Length	Sheet
α-helix	14	1
β-strand	15	1	1
β-strand	20-22	3	2
β-strand	25	1	3
α-helix	28-34	7
β-strand	47-48	2	4
β-strand	51-52	2	4
α-helix	53	1
α-helix	82-85	4
β-strand	86-94	9	5
α-helix	100-109	10
β-strand	110	1	6
β-strand	117	1	6
α-helix	124-132	9
α-helix	137-148	12
β-strand	153	1	7
β-strand	187	1	7
β-strand	190-194	5	8
β-strand	197-201	5	8
β-strand	214-216	3	8
α-helix	218-226	9
α-helix	230-235	6
α-helix	245-248	4
β-strand	250-255	6	5
α-helix	256	1
α-helix	272-274	3
α-helix	275-295	21
α-helix	300-318	19
α-helix	326-328	3
β-strand	329	1	9
α-helix	330	1
β-strand	335	1	9
α-helix	341-343	3
α-helix	349-353	5
β-strand	357-359	3	10
β-strand	362-369	8	11
β-strand	377-381	5	11
α-helix	382-387	6
β-strand	389-393	5	12
α-helix	399-408	10
β-strand	416-420	5	12
α-helix	425	1
β-strand	426-428	3	12
α-helix	435-438	4
β-strand	445-449	5	12
α-helix	450	1
β-strand	455-459	5	11
α-helix	466-468	3
β-strand	469-477	9	11
β-strand	482-484	3	11
α-helix	486-488	3
α-helix	489-492	4
β-strand	500-504	5	11
α-helix	509-518	10
β-strand	520	1	11
α-helix	522-524	3
β-strand	526-527	2	13
β-strand	532-533	2	13
α-helix	539-548	10
β-strand	554-555	2	14
α-helix	557-564	8
α-helix	574	1
β-strand	575	1	15
α-helix	576-577	2
β-strand	579-581	3	16
β-strand	585	1	16
β-strand	586-587	2	14
α-helix	588-595	8
β-strand	602-603	2	17
β-strand	629-631	3	17
β-strand	634-637	4	17
α-helix	642-645	4
α-helix	652-659	8
α-helix	662-683	22
β-strand	686	1	18
α-helix	689-692	4
α-helix	696-721	26
α-helix	726-728	3
α-helix	733-759	27
α-helix	765-771	7
α-helix	778-785	8
β-strand	789-790	2	19
β-strand	793	1	20
β-strand	796	1	20
α-helix	817-820	4
β-strand	822-823	2	19
α-helix	833-868	36
β-strand	872-873	2	21
β-strand	879-880	2	21
β-strand	886-888	3	21
α-helix	891-893	3
β-strand	896	1	22
β-strand	902-905	4	23
α-helix	913-920	8
α-helix	927-933	7
β-strand	934	1	24
α-helix	936-944	9
α-helix	946-969	24
β-strand	976-979	4	23
α-helix	983-993	11
β-strand	1002	1	24
α-helix	1006-1019	14
α-helix	1028-1037	10
α-helix	1039-1048	10
α-helix	1051-1056	6
α-helix	1062-1079	18
β-strand	1080	1	22
α-helix	1087-1101	15
α-helix	1121-1128	8
β-strand	1139-1142	4	25
β-strand	1143	1	26
α-helix	1146-1148	3
α-helix	1152-1161	10
β-strand	1164	1	27
α-helix	1166-1169	4
β-strand	1170-1177	8	28
α-helix	1187-1189	3
α-helix	1190-1198	9
β-strand	1207	1	29
β-strand	1210-1216	7	28
α-helix	1218-1224	7
α-helix	1228-1239	12
β-strand	1243-1247	5	28
β-strand	1256-1261	6	28
β-strand	1262	1	29
α-helix	1281-1295	15
β-strand	1299	1	27
β-strand	1307-1310	4	25
α-helix	1315-1317	3
β-strand	1319-1322	4	30
β-strand	1328-1331	4	30
β-strand	1335-1338	4	25
α-helix	1343-1347	5
β-strand	1352	1	26
β-strand	1358-1359	2	25
α-helix	1362-1369	8
α-helix	1371-1387	17
α-helix	1395-1404	10
α-helix	1416-1419	4
α-helix	1426-1432	7
α-helix	1435-1445	11
β-strand	1448-1449	2	2
α-helix	1455-1459	5
α-helix	1467-1469	3
β-strand	1472-1475	4	31
α-helix	1478-1480	3

Chain b: 13 helices, 70 β-strands

Element	Residues	Length	Sheet
β-strand	6-10	5	87
β-strand	17-21	5	88
β-strand	30-34	5	88
β-strand	38-45	8	88
β-strand	48-56	9	88
β-strand	61-67	7	89
β-strand	76-81	6	89
β-strand	85-94	10	89
β-strand	97-107	11	89
α-helix	114	1
β-strand	115	1	90
α-helix	116	1
β-strand	121-124	4	91
β-strand	130-134	5	91
β-strand	136	1	90
β-strand	141-144	4	91
β-strand	152-154	3	92
β-strand	155-156	2	91
β-strand	163-169	7	93
α-helix	170	1
β-strand	177-183	7	93
β-strand	188-195	8	93
β-strand	202-204	3	93
β-strand	210-212	3	93
β-strand	218-221	4	94
β-strand	229-232	4	94
β-strand	237-240	4	94
β-strand	245-248	4	94
α-helix	251-254	4
β-strand	258-263	6	95
β-strand	270-275	6	95
β-strand	279-289	11	95
β-strand	295-307	13	95
β-strand	313-318	6	96
β-strand	321-325	5	96
β-strand	331-336	6	96
β-strand	347-353	7	96
β-strand	362-365	4	97
α-helix	367-369	3
β-strand	374-379	6	97
β-strand	386-390	5	97
β-strand	712-716	5	97
β-strand	720-727	8	98
β-strand	732-743	12	98
β-strand	749-751	3	98
β-strand	762-765	4	98
β-strand	785-795	11	98
β-strand	801-806	6	98
β-strand	811-819	9	99
β-strand	828-835	8	99
β-strand	845-854	10	99
β-strand	857-862	6	99
β-strand	865-866	2	99
β-strand	870-876	7	100
β-strand	879-884	6	100
β-strand	887-893	7	100
β-strand	899-901	3	100
β-strand	911-917	7	101
β-strand	920-925	6	101
β-strand	928	1	102
β-strand	930-936	7	101
β-strand	941-947	7	101
β-strand	951	1	102
β-strand	954-959	6	103
β-strand	964-969	6	103
β-strand	974-978	5	103
α-helix	986-989	4
β-strand	991	1	101
β-strand	993-998	6	103
β-strand	1004-1009	6	87
β-strand	1025-1032	8	87
β-strand	1037-1042	6	87
α-helix	1045-1059	15
α-helix	1070-1073	4
β-strand	1076-1078	3	104
β-strand	1081-1083	3	104
β-strand	1086	1	103
β-strand	1090	1	87
α-helix	1091-1094	4
α-helix	1095-1097	3
α-helix	1102-1108	7
α-helix	1112-1114	3
α-helix	1126-1135	10

Chain B: 50 helices, 81 β-strands

Element	Residues	Length	Sheet
α-helix	19-36	18
α-helix	41-49	9
α-helix	50-54	5
α-helix	55-61	7
α-helix	63-65	3
β-strand	67-68	2	32
β-strand	83-84	2	32
β-strand	87-93	7	33
β-strand	97-99	3	34
β-strand	105-107	3	34
α-helix	108-109	2
α-helix	110-116	7
β-strand	121-131	11	33
β-strand	133	1	32
β-strand	141-153	13	33
α-helix	168-173	6
β-strand	185-187	3	35
β-strand	190-193	4	35
α-helix	194-195	2
β-strand	196-200	5	36
α-helix	201	1
β-strand	205-208	4	37
β-strand	215	1	38
β-strand	218-223	6	37
β-strand	233-239	7	37
β-strand	240	1	38
β-strand	256-259	4	37
β-strand	267-268	2	37
α-helix	269-276	8
α-helix	281-288	8
α-helix	295-307	13
α-helix	314-322	9
α-helix	332-341	10
α-helix	342-346	5
α-helix	358-377	20
α-helix	381-383	3
β-strand	391-394	4	36
α-helix	396-425	30
α-helix	431-434	4
α-helix	437-450	14
β-strand	453	1	39
β-strand	463	1	39
β-strand	468-469	2	35
α-helix	470-471	2
α-helix	475-482	8
β-strand	484-486	3	36
α-helix	503-505	3
β-strand	509	1	40
β-strand	524-525	2	36
β-strand	526	1	40
β-strand	531-532	2	41
α-helix	539-547	9
β-strand	551-552	2	42
α-helix	558-560	3
β-strand	565-569	5	42
β-strand	572-577	6	42
α-helix	580-591	12
β-strand	602-605	4	42
β-strand	611-615	5	42
β-strand	621-627	7	41
β-strand	628	1	43
β-strand	633	1	43
α-helix	637-644	8
α-helix	653-658	6
β-strand	662-666	5	41
α-helix	667-670	4
β-strand	675-676	2	41
α-helix	679-682	4
β-strand	695-696	2	41
α-helix	700-703	4
α-helix	714-716	3
α-helix	719-729	11
β-strand	732	1	44
β-strand	734	1	45
β-strand	747-751	5	45
β-strand	755	1	46
β-strand	759-760	2	47
α-helix	763-767	5
β-strand	776-782	7	48
β-strand	783	1	18
β-strand	793-797	5	48
α-helix	798-803	6
β-strand	808-817	10	45
β-strand	827-829	3	49
β-strand	848	1	50
β-strand	853	1	51
β-strand	854	1	50
α-helix	855	1
β-strand	859-860	2	45
β-strand	865-867	3	51
β-strand	869-871	3	49
β-strand	890-891	2	49
β-strand	894-895	2	51
α-helix	896-897	2
β-strand	902-911	10	45
β-strand	917-927	11	45
β-strand	934-936	3	48
β-strand	942-949	8	48
β-strand	956	1	52
β-strand	965-967	3	48
α-helix	971-975	5
α-helix	978-993	16
β-strand	997-998	2	47
α-helix	1008-1016	9
β-strand	1025-1026	2	48
β-strand	1029	1	52
α-helix	1035	1
β-strand	1036	1	52
α-helix	1037	1
β-strand	1041-1050	10	48
β-strand	1051	1	44
α-helix	1055-1057	3
β-strand	1060-1062	3	11
β-strand	1067	1	53
β-strand	1074	1	53
α-helix	1078-1080	3
β-strand	1084-1086	3	10
α-helix	1088-1097	10
α-helix	1100-1104	5
α-helix	1105-1109	5
β-strand	1115-1119	5	1
β-strand	1125	1	1
α-helix	1126	1
β-strand	1127-1128	2	54
β-strand	1135-1136	2	54
β-strand	1137	1	55
β-strand	1142	1	55
β-strand	1146-1150	5	1
α-helix	1153-1164	12
β-strand	1167	1	3
β-strand	1170-1172	3	2

Chain c: 0 helices, 3 β-strands

Element	Residues	Length	Sheet
β-strand	34	1	88
β-strand	45-46	2	89
β-strand	47-49	3	92

Chain C: 12 helices, 12 β-strands

Element	Residues	Length	Sheet
β-strand	8-14	7	56
β-strand	18-24	7	56
α-helix	28-40	13
β-strand	44-55	12	57
α-helix	61-69	9
β-strand	73	1	58
α-helix	78-81	4
β-strand	99-106	8	57
α-helix	112	1
β-strand	113-116	4	59
α-helix	117-119	3
β-strand	121-122	2	57
β-strand	129	1	58
α-helix	130-132	3
α-helix	147-148	2
β-strand	149-153	5	59
β-strand	158-168	11	57
α-helix	174-176	3
β-strand	179-185	7	56
α-helix	200-202	3
α-helix	204-206	3
α-helix	218-220	3
β-strand	229-235	7	56
α-helix	241-269	29

Chain d: 18 helices, 6 β-strands

Element	Residues	Length	Sheet
α-helix	3-13	11
α-helix	22-34	13
α-helix	36-50	15
α-helix	55-70	16
α-helix	73-81	9
α-helix	83-91	9
α-helix	97-100	4
α-helix	102	1
α-helix	103-124	22
α-helix	129-136	8
α-helix	137-141	5
β-strand	570	1	113
α-helix	575	1
β-strand	576	1	113
α-helix	577	1
β-strand	584-585	2	114
β-strand	589-590	2	114
β-strand	594	1	115
β-strand	600	1	115
α-helix	603-618	16
α-helix	659-660	2
α-helix	661-665	5
α-helix	668-676	9
α-helix	679-696	18

Chain D: 10 helices, 2 β-strands

Element	Residues	Length	Sheet
β-strand	16	1	60
β-strand	21	1	60
α-helix	30-31	2
α-helix	34-49	16
α-helix	55-58	4
α-helix	59-70	12
α-helix	77-89	13
α-helix	94-103	10
α-helix	108-114	7
α-helix	116-118	3
α-helix	124-137	14
α-helix	139-140	2

11 more chain groups are not listed. Open the entry in the viewer and use the sequence panel to see them.

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
DNA-directed RNA polymerase subunit	A	protein	1970	Sus scrofa domesticus	A0A8D1DPV6
DNA-directed RNA polymerase subunit beta	B	protein	1300	Sus scrofa domesticus	I3LGP4 (AlphaFold model)
DNA-directed RNA polymerase II subunit RPB3	C	protein	275	Sus scrofa domesticus	I3LCH3 (AlphaFold model)
RNA polymerase II subunit D	D	protein	142	Sus scrofa domesticus	A0A4X1VM56 (AlphaFold model)
DNA-directed RNA polymerase II subunit E	E	protein	210	Sus scrofa domesticus	I3LSI7
DNA-directed RNA polymerases I, II, and III subunit RPABC2	F	protein	127	Sus scrofa domesticus	A0A4X1VEK9
DNA-directed RNA polymerase subunit	G	protein	172	Sus scrofa domesticus	A0A4X1VKG7
DNA-directed RNA polymerases I, II, and III subunit RPABC3	H	protein	150	Sus scrofa domesticus	I3LCB2
DNA-directed RNA polymerase II subunit RPB9	I	protein	125	Sus scrofa domesticus	P60899
DNA-directed RNA polymerases I, II, and III subunit RPABC5	J	protein	67	Sus scrofa domesticus	A0A8W4F9W9
DNA-directed RNA polymerase II subunit RPB11-a	K	protein	117	Sus scrofa domesticus	F1RKE4
RNA polymerase II, I and III subunit K	L	protein	58	Sus scrofa domesticus	A0A4X1TRS6

10 more molecules are not listed.

Sequence of entity 1 (A), FASTA

>9FD2_1 DNA-directed RNA polymerase subunit (chains A)
MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVD
SNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKG
HGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEP
RYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAA
HVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVD
FSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYII
RDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWS
TFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQD
TLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHI
NCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEM
GHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKA
HNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKIN
ISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHA
MGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGES
VEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMR
EDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKL
VIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAI
AHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLT
VFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMP
DFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIR
IMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKI
IITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALER
ELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLM
EAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTG
MFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPG
YSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSP
SYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSP
TSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPS
YSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPT
SPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKY
SPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTS
PKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Sequence of entity 2 (B), FASTA

>9FD2_2 DNA-directed RNA polymerase subunit beta (chains B)
MKPLRPENPPKAELKGLLFVQQHCKTRLHSVAVTRPRGAATEESTPKLRMCSTNLSQALA
YFRAGANLTAASLWAGFRGSRRIFWERRKRKSLCLALRPGGACWRWLLAVSCVSLRGLGA
PGSCANMYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMS
VQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEAR
LRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCEL
NECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTST
IWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFED
PEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVS
DFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKE
VRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLT
FASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISV
GSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQM
DIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQ
DLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFP
DHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPA
GINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTR
ETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCST
FLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDM
PFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNL
LSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQP
MEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHT
YECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Sequence of entity 3 (C), FASTA

>9FD2_3 DNA-directed RNA polymerase II subunit RPB3 (chains C)
MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLH
DEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDL
ISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTA
GVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLR
PETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Sequence of entity 4 (D), FASTA

>9FD2_4 RNA polymerase II subunit D (chains D)
MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEV
FMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEG
RFEDEELQQILDDIQTKRSFQY

Sequence of entity 5 (E), FASTA

>9FD2_5 DNA-directed RNA polymerase II subunit E (chains E)
MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTV
LVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVD
MAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVA
RYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Sequence of entity 6 (F), FASTA

>9FD2_6 DNA-directed RNA polymerases I, II, and III subunit RPABC2 (chains F)
MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKY
ERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGV
DELIISD

Sequence of entity 7 (G), FASTA

>9FD2_7 DNA-directed RNA polymerase subunit (chains G)
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQ
PGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFD
PNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Sequence of entity 8 (H), FASTA

>9FD2_8 DNA-directed RNA polymerases I, II, and III subunit RPABC3 (chains H)
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGG
LLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Sequence of entity 9 (I), FASTA

>9FD2_9 DNA-directed RNA polymerase II subunit RPB9 (chains I)
MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITH
EVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCG
HRWTE

Sequence of entity 10 (J), FASTA

>9FD2_10 DNA-directed RNA polymerases I, II, and III subunit RPABC5 (chains J)
MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLL
NYAPLEK

Sequence of entity 11 (K), FASTA

>9FD2_11 DNA-directed RNA polymerase II subunit RPB11-a (chains K)
MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAG
YKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Sequence of entity 12 (L), FASTA

>9FD2_12 RNA polymerase II, I and III subunit K (chains L)
MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Ligands and cofactors

ID	Name	Formula	Copies
ZN	Zinc ion	Zn	10
MG	Magnesium ion	Mg	1

Primary citation

STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. Ramadhin, A.R., Lee, S.H., Zhou, D. et al. Mol Cell (2024) 84:4740. DOI 10.1016/j.molcel.2024.10.030 · PubMed

Other PDB entries of the same protein (UniProt A0A8D1DPV6), best resolution first:

9HVQ 2.0 Å, Structure of the transcribing Pol II-DSIF-PAF-SPT6-RECQL5 complex
7NVU 2.5 Å, RNA polymerase II core pre-initiation complex with open promoter DNA
8QEP 2.5 Å, RNA polymerase II bound to Alu RNA right arm
8B3D 2.6 Å, Structure of the Pol II-TCR-ELOF1 complex.
7OOB 2.7 Å, Pol II-CSB-CSA-DDB1-UVSSA-ADPBeF3 (Structure2)
8UHG 2.7 Å, Structure of paused transcription complex Pol II-DSIF-NELF - poised post-translocated
8UI0 2.7 Å, Structure of poised transcription complex Pol II-DSIF-NELF - pre-translocated
8WAV 2.72 Å, De novo transcribing complex 12 (TC12), the early elongation complex with Pol II…
8WAX 2.75 Å, De novo transcribing complex 14 (TC14), the early elongation complex with Pol II…
8WAZ 2.76 Å, De novo transcribing complex 16 (TC16), the early elongation complex with Pol II…
7F4G 2.78 Å, Structure of RPAP2-bound RNA polymerase II
8WAU 2.78 Å, De novo transcribing complex 11 (TC11), the early elongation complex with Pol II…

Browse structure collections

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