Matrix metalloproteinase-14 (MMP14) is a 582-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P50281.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 80.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 56% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 18% |
What pLDDT means and how to read it
Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed:8015608). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed:22065321, PubMed:8015608). Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657, PubMed:22065321). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1 (PubMed:21572390).…
Interacts (via C-terminal cytoplasmic tail) with BST2
Cell membrane, Melanosome, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3C7X | X-ray | 1.7 Å | A=316-511 |
| 4P3C | X-ray | 1.94 Å | M=215-227 |
| 4P3D | X-ray | 1.95 Å | C/M=215-227 |
| 3MA2 | X-ray | 2.05 Å | A/D=112-292 |
| 5H0U | X-ray | 2.24 Å | A=116-285 |
| 4QXU | X-ray | 2.3 Å | K=218-228 |
| 3X23 | X-ray | 2.4 Å | B=563-582 |
| 1BQQ | X-ray | 2.75 Å | M=114-287 |
| 1BUV | X-ray | 2.75 Å | M=114-287 |
| 2MQS | NMR | A=316-511 | |
| 6CLZ | NMR | A=316-511 | |
| 6CM1 | NMR | A=316-511 |
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