SWI/SNF-related matrix-associated actin-dependent regulator of chromatin… (SMARCA2) is a 1590-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51531.
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The mean pLDDT of this model is 65.1 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 34% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 34% |
What pLDDT means and how to read it
ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically (PubMed:15075294, PubMed:22952240, PubMed:26601204). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as…
Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B, mutually exclusive) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6HAZ | X-ray | 1.31 Å | A/B=1373-1511 |
| 7Z76 | X-ray | 1.32 Å | D=1373-1511 |
| 7Z78 | X-ray | 1.32 Å | A/B/C=1373-1511 |
| 5DKC | X-ray | 1.6 Å | A=1373-1511 |
| 9D11 | X-ray | 1.68 Å | A/B/C=1373-1511 |
| 5DKH | X-ray | 1.7 Å | A/B/C=1373-1511 |
| 9E30 | X-ray | 1.71 Å | A/B/C=1373-1511 |
| 9E31 | X-ray | 1.96 Å | A/B/C=1373-1511 |
| 4QY4 | X-ray | 1.97 Å | A/B/C=1373-1511 |
| 7Z77 | X-ray | 1.97 Å | D=1373-1511 |
| 9QAC | X-ray | 2.07 Å | A/B/C=1373-1511 |
| 9QAD | X-ray | 2.08 Å | A/B/C=1373-1511 |
| 9D12 | X-ray | 2.1 Å | A/B/C=1373-1511 |
| 9HYP | X-ray | 2.2 Å | A=1373-1511 |
| 6HAY | X-ray | 2.24 Å | A/E=1373-1511 |
| 7Z6L | X-ray | 2.24 Å | A=1373-1511 |
| 7S4E | X-ray | 2.25 Å | A/E=1373-1511 |
| 9E1K | X-ray | 2.26 Å | A/B/C=1373-1511 |
| 6HAX | X-ray | 2.35 Å | A/E=1373-1511 |
| 9HYN | X-ray | 2.37 Å | G/H=1373-1511 |
Showing 20 of 31 experimental structures (best resolution first).
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