SWI/SNF-related matrix-associated actin-dependent regulator of chromatin… (SMARCA4) is a 1647-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P51532.
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The mean pLDDT of this model is 64.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 31% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 37% |
What pLDDT means and how to read it
ATPase involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (PubMed:15075294, PubMed:29374058, PubMed:30339381, PubMed:32459350). Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by…
Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7TAB | X-ray | 1.16 Å | A=1448-1575 |
| 2GRC | X-ray | 1.5 Å | A=1448-1575 |
| 6ZS2 | X-ray | 1.57 Å | A/B=1451-1569 |
| 7TD9 | X-ray | 1.61 Å | AAA/BBB/CCC=1448-1575 |
| 6HR2 | X-ray | 1.76 Å | A/E=1449-1568 |
| 3UVD | X-ray | 1.85 Å | A=1448-1569 |
| 5DKD | X-ray | 2.0 Å | A/B=1451-1569 |
| 5EA1 | X-ray | 2.0 Å | A/B/C=1451-1580 |
| 9DTX | X-ray | 2.11 Å | D=1448-1569 |
| 7VRB | X-ray | 2.39 Å | A/B/C/D=172-213 |
| 7VDT | EM | 2.8 Å | A=160-1647 |
| 9WBZ | EM | 2.9 Å | A=1-1647 |
| 6LTH | EM | 3.0 Å | I=1-1647 |
| 9UX9 | EM | 3.05 Å | K=2-1647 |
| 8QJR | X-ray | 3.17 Å | G/H=1451-1569 |
| 7VDV | EM | 3.4 Å | A=160-1647 |
| 9WC1 | EM | 3.4 Å | D=1-1647 |
| 9RL4 | EM | 3.5 Å | I=1-1647 |
| 6LTJ | EM | 3.7 Å | I=1-1647 |
| 8G1Q | X-ray | 3.73 Å | H=1447-1569 |
Showing 20 of 28 experimental structures (best resolution first).
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