P53350: Serine/threonine-protein kinase PLK1
Serine/threonine-protein kinase PLK1 (PLK1) is a 603-residue protein from Homo sapiens. UniProt accession: P53350.
Function
Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis (PubMed:11202906, PubMed:12207013, PubMed:12447691, PubMed:12524548, PubMed:12738781, PubMed:12852856, PubMed:12939256, PubMed:14532005, PubMed:14734534, PubMed:15070733, PubMed:15148369, PubMed:15469984, PubMed:16198290, PubMed:16247472, Pub
Subcellular location
Nucleus, Chromosome, centromere, kinetochore, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle, Midbody
Subunit structure
Interacts with CEP170 (PubMed:15616186). Interacts with EVI5 (PubMed:16439210). Interacts with FAM29A (PubMed:19029337). Interacts with SLX4/BTBD12 (PubMed:19596235). Interacts with TTDN1 (PubMed:17310276). Interacts (via POLO-box domain) with the phosphorylated form of BUB1, CDC25C and CENPU (PubMed:14532005, PubMed:16760428, PubMed:17307877, PubMed:19597481). Interacts with KIF2A (PubMed:1935171
View this AlphaFold prediction interactively in 3D with MolViewer. Rotate, zoom, measure distances and angles, and explore the predicted structure directly in your browser without installing any software.