Talin-1 (TLN1) is a 2541-residue protein from Gallus gallus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P54939.
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The mean pLDDT of this model is 76.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 3% |
| 70 to 90 | Confident: backbone generally right | 77% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Involved in connections of major cytoskeletal structures to the plasma membrane
Interacts with PIP5K1C and NRAP (By similarity). Binds with high affinity to vinculin VCL and with low affinity to integrins (PubMed:12535520, PubMed:14702644, PubMed:20610383, PubMed:8937989). Interacts with APBB1IP; this inhibits VCL binding (By similarity). Interacts with F-actin (PubMed:8937989). Interacts with LAYN (PubMed:9786953). Interacts with THSD1
Cell projection, ruffle membrane, Cytoplasm, cytoskeleton, Cell surface, Cell junction, focal adhesion
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1MIX | X-ray | 1.75 Å | A=196-400 |
| 1ZVZ | X-ray | 1.8 Å | B=820-844 |
| 1MIZ | X-ray | 1.9 Å | B=200-400 |
| 1ZW2 | X-ray | 2.1 Å | B=2344-2368 |
| 1MK7 | X-ray | 2.2 Å | B/D=209-400 |
| 1U6H | X-ray | 2.38 Å | B=849-879 |
| 1XWJ | X-ray | 2.6 Å | B=1944-1969 |
| 1RKC | X-ray | 2.7 Å | B=1944-1969 |
| 8S4Y | X-ray | 2.7 Å | B=209-400 |
| 1MK9 | X-ray | 2.8 Å | B/D/F/H=209-400 |
| 2H7D | NMR | A=309-405 | |
| 2H7E | NMR | A=309-405 | |
| 2HRJ | NMR | A=189-309 | |
| 2K00 | NMR | A=309-400 |
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