Syntaxin-binding protein 1 (Stxbp1) is a 594-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P61765.
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The mean pLDDT of this model is 90.5 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 80% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 4% |
What pLDDT means and how to read it
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (PubMed:21689256). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions
Interacts with SYTL4 (PubMed:12058058). Interacts with STX1A (PubMed:10746715). The interaction recruits SNARE complex components SNAP25 and VAMP2 and mediates neurotransmitter release from neurons (By similarity). Interacts with alpha-synuclein/SNCA; this interaction controls SNCA self-replicating aggregation (By similarity). Interacts with RAB3A; this interaction promotes RAB3A dissociation…
Cytoplasm, cytosol, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4JEH | X-ray | 2.5 Å | A=1-594 |
| 3C98 | X-ray | 2.6 Å | A=1-594 |
| 4JEU | X-ray | 3.2 Å | A=3-592 |
| 7XSJ | X-ray | 3.2 Å | A=1-594 |
| 3PUJ | X-ray | 3.31 Å | A/B=1-594 |
| 6LPC | X-ray | 3.4 Å | A/B=1-594 |
| 7UDB | EM | 3.5 Å | A=1-594 |
| 7UDC | EM | 3.7 Å | A=1-594 |
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