Calmodulin (Cam) is a 149-residue protein from Drosophila melanogaster. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62152.
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The mean pLDDT of this model is 85.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 46% |
| 70 to 90 | Confident: backbone generally right | 44% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 2% |
What pLDDT means and how to read it
Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes (PubMed:23226104). Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance (PubMed:10480937, PubMed:29444420)
Interacts with Crag (PubMed:18331716). Interacts with stac (PubMed:9813038). Interacts with Akap200; the interaction is calcium-dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937)
Cytoplasm, cell cortex
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1MXE | X-ray | 1.7 Å | A/B=2-149 |
| 7CQH | X-ray | 2.15 Å | B=79-149 |
| 2X51 | X-ray | 2.2 Å | B=1-149 |
| 3L9I | X-ray | 2.2 Å | C=1-149 |
| 4CLN | X-ray | 2.2 Å | A=2-149 |
| 4DBP | X-ray | 2.2 Å | C=1-149 |
| 8ZLW | X-ray | 2.2 Å | N=1-149 |
| 2BKH | X-ray | 2.4 Å | B=1-149 |
| 2VAS | X-ray | 2.4 Å | B=1-149 |
| 4PJJ | X-ray | 2.4 Å | B=1-149 |
| 4ANJ | X-ray | 2.6 Å | B=1-149 |
| 4DBQ | X-ray | 2.6 Å | B=1-149 |
| 3GN4 | X-ray | 2.7 Å | B/D/F/H=1-149 |
| 2BBM | NMR | A=2-149 | |
| 2BBN | NMR | A=2-149 |
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