Calmodulin (CALM) is a 149-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62157.
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The mean pLDDT of this model is 84.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 43% |
| 70 to 90 | Confident: backbone generally right | 47% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Calcium-binding is required for the activation of calmodulin. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Is a regulator of voltage-dependent L-type calcium channels. Mediates calcium-dependent…
Homotetramer (By similarity). Interacts with CEP97, CCP110, TTN/titin and SRY. Interacts with MYO5A and RRAD (By similarity). Interacts with USP6; the interaction is calcium dependent (By similarity). Interacts with CDK5RAP2. Interacts with SCN5A. Interacts with RYR1 and RYR2 (By similarity). Interacts with FCHO1. Interacts with MIP in a 1:2 stoichiometry; the interaction with the cytoplasmic…
Cytoplasm, Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, spindle pole
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3IF7 | X-ray | 1.6 Å | A=2-149 |
| 1FW4 | X-ray | 1.7 Å | A=79-149 |
| 1PRW | X-ray | 1.7 Å | A=2-149 |
| 1CDM | X-ray | 2.0 Å | A=5-148 |
| 1CM1 | X-ray | 2.0 Å | A=2-149 |
| 1CM4 | X-ray | 2.0 Å | A=2-149 |
| 1LIN | X-ray | 2.0 Å | A=2-149 |
| 1XA5 | X-ray | 2.12 Å | A=2-149 |
| 2F2O | X-ray | 2.17 Å | A/B=1-149 |
| 1QIW | X-ray | 2.3 Å | A/B=2-149 |
| 2FOT | X-ray | 2.45 Å | A=2-149 |
| 2F2P | X-ray | 2.6 Å | A/B=1-149 |
| 1QIV | X-ray | 2.64 Å | A=2-149 |
| 1A29 | X-ray | 2.74 Å | A=2-149 |
| 1DEG | X-ray | 2.9 Å | A=6-148 |
| 6O20 | EM | 3.3 Å | F=1-149 |
| 1AK8 | NMR | A=1-76 | |
| 1CMF | NMR | A=77-149 | |
| 1CMG | NMR | A=77-149 |
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