E3 ubiquitin-protein ligase RBX1 (RBX1) is a 108-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P62877.
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The mean pLDDT of this model is 79.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 24% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 21% |
| Below 50 | Very low: often disordered regions | 7% |
What pLDDT means and how to read it
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair (PubMed:10230407, PubMed:10579999, PubMed:11961546, PubMed:15983046, PubMed:16678110, PubMed:19112177, PubMed:19679664, PubMed:22748924, PubMed:23455478, PubMed:27565346, PubMed:29769719, PubMed:32355176, PubMed:33417871, PubMed:37844242, PubMed:38326650, PubMed:39504960, PubMed:39667934, PubMed:38316879). CRLs complexes and ARIH1 collaborate in tandem to…
Component of multiple Cul1-RING E3 ubiquitin-protein ligase complexes commonly known as SCF (SKP1-CUL1-F-box) complexes, consisting of CUL1, SKP1, RBX1 and a variable F-box domain-containing protein (PubMed:10230406, PubMed:11961546, PubMed:20596027, PubMed:22748924, PubMed:38326650, PubMed:39880951). Part of a SCF(SKP2) complex consisting of CUL1, RBX1, SKP1 and SKP2 (PubMed:10230406,…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3DPL | X-ray | 2.6 Å | R=5-108 |
| 7Z8R | EM | 2.7 Å | R=5-108 |
| 7Z8V | EM | 2.7 Å | R=5-108 |
| 7PLO | EM | 2.8 Å | T=1-108 |
| 7Z8B | EM | 2.8 Å | R=1-108 |
| 8OR3 | EM | 2.9 Å | B=1-108 |
| 9QO4 | EM | 2.95 Å | J=1-108 |
| 9EFQ | EM | 2.96 Å | K=1-108 |
| 1LDJ | X-ray | 3.0 Å | B=19-108 |
| 3DQV | X-ray | 3.0 Å | R/Y=5-108 |
| 4F52 | X-ray | 3.0 Å | B/D=5-108 |
| 7Z8T | EM | 3.0 Å | R=5-108 |
| 9EFV | EM | 3.03 Å | K=1-108 |
| 1LDK | X-ray | 3.1 Å | C=19-108 |
| 1U6G | X-ray | 3.1 Å | B=1-108 |
| 2HYE | X-ray | 3.1 Å | D=1-108 |
| 7ZBZ | EM | 3.1 Å | R=5-108 |
| 8OR0 | EM | 3.1 Å | B=1-108 |
| 4P5O | X-ray | 3.11 Å | B/D=3-108 |
| 9XZJ | EM | 3.13 Å | R=1-108 |
Showing 20 of 99 experimental structures (best resolution first).
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