Tubulin beta-4B chain (Tubb4b) is a 445-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P68372.
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The mean pLDDT of this model is 92.1 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 83% |
| 70 to 90 | Confident: backbone generally right | 13% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13…
Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, flagellum axoneme
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8IYJ | EM | 3.5 Å | AB/AD/AF/AH/AJ/AL/AN/AP/BB/BD/BF/BH/BJ/BL/BN/BP/CB/CD/CF/CH/CJ/CL/CN/CP/DB/DD/DF/DH/DJ/DL=1-445 |
| 9XRL | EM | 3.74 Å | AE/AN/t=1-430 |
| 9SFP | EM | 4.2 Å | b=1-430 |
| 8I7O | EM | 4.5 Å | AF/AH/BF/BH/CF/CH/CJ/DD/DF/DH/ED/EF/EH/FD/FF/FH/GD/GF/GH/HD/HF/HH/IF/IH/JD/JF/JH/KD/KF/KH=1-427 |
| 8I7R | EM | 6.5 Å | AB/AD/AF/AH/AJ/AL/BB/BD/BF/BH/BJ/BL/CB/CD/CF/CH/CJ/CL/DB/DD/DF/DH/DJ/DL/EB/ED/EF/EH/EJ/EL=1-427 |
| 8TO0 | EM | 7.7 Å | A0/A4/A6/A8/AN/AP/AR/AT/AV/AX/Ak/Am/Ao/Aq/As/Au/Aw/B1/B3/B7/B9/BB/BD/BF/BN/BP/BR/BT/BV/BX=1-445 |
| 9IJJ | EM | 7.7 Å | Ab/Ad/Af/Ah/Aj/An/Ap/Ar/At/Av/Bb/Bd/Bf/Bh/Bj/Bn/Bp/Br/Bt/Bv/Cb/Cd/Cf/Ch/Cj/Cn/Cp/Cr/Ct/Cv=1-445 |
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