G-protein-signaling modulator 2 (GPSM2) is a 684-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: P81274.
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The mean pLDDT of this model is 66.9 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 45% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 41% |
What pLDDT means and how to read it
Plays an important role in mitotic spindle pole organization via its interaction with NUMA1 (PubMed:11781568, PubMed:15632202, PubMed:21816348). Required for cortical dynein-dynactin complex recruitment during metaphase (PubMed:22327364). Plays a role in metaphase spindle orientation (PubMed:22327364). Also plays an important role in asymmetric cell divisions (PubMed:21816348). Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity (By similarity)
Interacts with the dynein-dynactin complex; this interaction is inhibited in a PLK1-dependent manner (PubMed:22327364). Part of a spindle orientation complex at least composed of GNAI1, GPSM2 and NUMA1 (PubMed:26766442). Interacts with LLGL2 (PubMed:15632202). Interacts (via TPR repeat region) with INSC/inscuteable (PubMed:16458856, PubMed:22074847). Interacts (via TPR repeat region) with NUMA1…
Cytoplasm, Cytoplasm, cell cortex, Cytoplasm, cytoskeleton, spindle pole, Lateral cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4WND | X-ray | 1.5 Å | A=20-421 |
| 4WNE | X-ray | 2.0 Å | A=20-421 |
| 4WNG | X-ray | 2.11 Å | A=20-421 |
| 3SF4 | X-ray | 2.6 Å | A/B/C=20-421 |
| 4WNF | X-ray | 2.9 Å | A=20-421 |
| 5A6C | X-ray | 2.9 Å | A/B=22-357 |
| 6HC2 | X-ray | 4.31 Å | A/C/E/G/I/K/M/O/Q/S/U/W=14-374 |
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