Nuclear factor NF-kappa-B p100 subunit (NFKB2) is a 900-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q00653.
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The mean pLDDT of this model is 74.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 38% |
| 70 to 90 | Confident: backbone generally right | 34% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different…
Component of the NF-kappa-B RelB-p52 complex. Homodimer; component of the NF-kappa-B p52-p52 complex. Component of the NF-kappa-B p65-p52 complex. Component of the NF-kappa-B p52-c-Rel complex. NFKB2/p52 interacts with NFKBIE. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Directly interacts with MEN1
Nucleus, Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1A3Q | X-ray | 2.1 Å | A/B=37-327 |
| 8G8S | X-ray | 2.1 Å | B=309-343 |
| 8G8Q | X-ray | 2.6 Å | B=332-348 |
| 5ZMC | X-ray | 2.99 Å | A=35-329 |
| 7CLI | X-ray | 3.0 Å | A/B=1-398 |
| 7W7L | X-ray | 3.0 Å | A/B=1-327 |
| 3DO7 | X-ray | 3.05 Å | B=37-329 |
| 7VUQ | X-ray | 3.1 Å | A/B=1-398 |
| 4OT9 | X-ray | 3.35 Å | A=407-765 |
| 7VUP | X-ray | 3.4 Å | A/B=1-398 |
| 2D96 | NMR | A=766-859 |
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