Histone promoter control protein 2 (HPC2) is a 625-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q01448.
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The mean pLDDT of this model is 53.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 0% |
| 70 to 90 | Confident: backbone generally right | 17% |
| 50 to 70 | Low: treat with caution | 25% |
| Below 50 | Very low: often disordered regions | 58% |
What pLDDT means and how to read it
Component of the HIR complex, which functions as a histone chaperone that cooperates with ASF1 to promote replication-independent chromatin assembly. The HIR complex is also required for the periodic repression of three of the four histone gene loci during cell cycle as well as for autogenous regulation of the HTA1-HTB1 locus by H2A and H2B. DNA-binding by the HIR complex may repress transcription by inhibiting nucleosome remodeling by the SWI/SNF complex. The HIR complex may also be required for transcriptional silencing of centromeric, telomeric and mating-type loci in the absence of CAF-1
Component of the HIR complex, composed of HIR1, HIR2, HIR3 and HPC2 (PubMed:16264190, PubMed:16303565). This complex may consist of one copy of HIR1 and HIR3 and two copies of HIR2 and HPC2 (PubMed:16264190). The HIR complex interacts with ASF1 (PubMed:16303565). Interacts with RTT106 (PubMed:19683497)
Nucleus, Chromosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9J5E | X-ray | 1.9 Å | B=448-468 |
| 8GHN | EM | 2.96 Å | E/F/K/L=1-625 |
| 8GHA | EM | 6.8 Å | E=1-625 |
| 8GHM | EM | 12.0 Å | F/L=1-625 |
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