Myocyte-specific enhancer factor 2A (MEF2A) is a 507-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q02078.
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The mean pLDDT of this model is 54.7 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 17% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 67% |
What pLDDT means and how to read it
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter
Binds DNA as a homo- or heterodimer. Dimerizes with MEF2D. Interacts with HDAC7 (By similarity). Interacts with PIAS1; the interaction enhances sumoylation. Interacts with HDAC4, HDAC9 and SLC2A4RG. Interacts (via the N-terminal) with MAPK7; the interaction results in the phosphorylation and transcriptional activity of MEF2A
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1EGW | X-ray | 1.5 Å | A/B/C/D=2-78 |
| 6WC2 | X-ray | 2.1 Å | A/B/C/D/I/J=9-72, A/B/C/D/I/J=92-95 |
| 3P57 | X-ray | 2.19 Å | A/B/C/D/I/J=2-91 |
| 1LEW | X-ray | 2.3 Å | B=269-280 |
| 6BYY | X-ray | 2.3 Å | A/B/C/D=1-64, A/B/C/D=92-95 |
| 3MU6 | X-ray | 2.43 Å | A/B/C/D=2-72 |
| 3KOV | X-ray | 2.9 Å | A/B/I/J=2-91 |
| 6BZ1 | X-ray | 2.97 Å | A/B/C/D=1-64, A/B/C/D=92-95 |
| 7XUZ | X-ray | 3.59 Å | C/D/G/H=1-95 |
| 1C7U | NMR | A/B=2-86 |
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