Vacuolar protein sorting-associated protein 28 (VPS28) is a 242-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q02767.
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The mean pLDDT of this model is 81.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 35% |
| 70 to 90 | Confident: backbone generally right | 48% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for normal endocytic and biosynthetic traffic to the yeast vacuole
Component of the ESCRT-I complex (endosomal sorting complex required for transport I) which consists of STP22, VPS28, SRN2 and MVB12 in a 1:1:1:1 stoichiometry. Self-associates. Interacts with VPS27; the interaction mediates the association with the ESCRT-0 complex. Interacts with VPS20; the interaction mediates the association with the ESCRT-III complex
Cytoplasm, Endosome, Late endosome membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2J9U | X-ray | 2.0 Å | A/C=148-242 |
| 2J9V | X-ray | 2.0 Å | A=148-242 |
| 2F6M | X-ray | 2.1 Å | B/D=13-118 |
| 2P22 | X-ray | 2.7 Å | B=1-118 |
| 2F66 | X-ray | 2.8 Å | B/E=13-125 |
| 2G3K | X-ray | 3.05 Å | A/B/C/D/E/F/G=148-241 |
| 2CAZ | X-ray | 3.6 Å | B/E=1-147 |
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