Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4) is a 459-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q02790.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 90.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 84% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 9% |
What pLDDT means and how to read it
Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria
Homodimer (By similarity). Interacts with GLMN (PubMed:12604780). Associates with HSP90AA1 and HSP70 in steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with NR3C1 and dynein. Interacts with HSF1 in the HSP90 complex. Associates with tubulin. Interacts with MAPT/TAU (By similarity). Interacts (via TPR domain) with S100A1,…
Cytoplasm, cytosol, Mitochondrion, Nucleus, Cytoplasm, cytoskeleton, Cell projection, axon
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4LAY | X-ray | 1.7 Å | A=1-260 |
| 4DRJ | X-ray | 1.8 Å | A=1-140 |
| 4LAV | X-ray | 1.8 Å | A/B=16-260 |
| 1Q1C | X-ray | 1.9 Å | A=2-260 |
| 4LAX | X-ray | 2.01 Å | A=16-260 |
| 6RCY | X-ray | 2.3 Å | A=1-148 |
| 1N1A | X-ray | 2.4 Å | A/B=1-140 |
| 4LAW | X-ray | 2.4 Å | A/B=16-260 |
| 1P5Q | X-ray | 2.8 Å | A/B/C=146-459 |
| 1QZ2 | X-ray | 3.0 Å | A/B/C=145-459 |
| 4TW8 | X-ray | 3.0 Å | A/B=21-255 |
| 8FFV | EM | 3.01 Å | D=1-459 |
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