6RCY: FK1 domain of FKBP52

Crystal structure of FK1 domain of FKBP52 in complex with a bio-inspired hybrid fluorescent ligand. Determined by X-ray diffraction at 2.3 Å resolution. Released 13 May 2020.

Method: X-ray diffraction
Resolution: 2.3 Å
Organism: Homo sapiens
Chains: 1
Atoms: 1,077
Mol. weight: 16.91 kDa
Ligands: K0T
Released: 13 May 2020

Explore 6RCY in 3D Show helices and sheets RCSB PDB PDBe

Secondary structure: helices and β-sheets

6RCY contains 5 α-helices and 10 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.

Chain A: 5 helices, 10 β-strands

Element	Residues	Length	Sheet
β-strand	23-24	2	1
β-strand	33-39	7	1
α-helix	47-48	2
β-strand	52-61	10	1
β-strand	66-69	4	1
α-helix	70-72	3
β-strand	77-80	4	1
α-helix	88-94	7
α-helix	97-98	2
β-strand	102-107	6	1
α-helix	109-111	3
β-strand	118	1	2
β-strand	122	1	2
β-strand	128-138	11	1
β-strand	143-145	3	1

Molecules and chains

Molecule	Chains	Type	Length	Organism	UniProt
Peptidyl-prolyl cis-trans isomerase FKBP4	A	protein	148	Homo sapiens	Q02790 (AlphaFold model)

Sequence of entity 1 (A), FASTA

>6RCY_1 Peptidyl-prolyl cis-trans isomerase FKBP4 (chains A)
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGW
LLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPP
KIPPNATLVFEVELFEFKGEDLTEEEDG

Ligands and cofactors

ID	Name	Formula	Copies
K0T	(2~{S})-5-carbamimidamido-2-[[(2~{S})-2-[[(2~{S})-1-[5-(dimethylamino)naphthale…	C34 H45 N7 O6 S	1

Primary citation

Bioinspired Hybrid Fluorescent Ligands for the FK1 Domain of FKBP52. de la Sierra-Gallay, I.L., Belnou, M., Chambraud, B. et al. J Med Chem (2020) 63:10330-10338. DOI 10.1021/acs.jmedchem.0c00825 · PubMed

Other PDB entries of the same protein (UniProt Q02790 (AlphaFold model), which also has an AlphaFold model), best resolution first:

4LAY 1.7 Å, Crystal Structure Analysis of FKBP52, Complex with I63
4DRJ 1.8 Å, o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
4LAV 1.8 Å, Crystal Structure Analysis of FKBP52, Crystal Form II
1Q1C 1.9 Å, Crystal structure of N(1-260) of human FKBP52
4LAX 2.01 Å, Crystal Structure Analysis of FKBP52, Complex with FK506
1N1A 2.4 Å, Crystal Structure of the N-terminal domain of human FKBP52
4LAW 2.4 Å, Crystal Structure Analysis of FKBP52, Crystal Form III
1P5Q 2.8 Å, Crystal Structure of FKBP52 C-terminal Domain
1QZ2 3.0 Å, Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD…
4TW8 3.0 Å, The Fk1-Fk2 domains of FKBP52 in complex with iFit-FL
8FFV 3.01 Å, Cryo-EM structure of the GR-Hsp90-FKBP52 complex

Browse structure collections

About this viewer

MolViewer shows 6RCY directly in your browser with nothing to install. Switch between cartoon, ball-and-stick, spacefill and surface views, color by chain, secondary structure or B-factor, measure distances, angles and dihedrals, and share or embed the view.