RNA polymerase II transcription factor B subunit 3 (TFB3) is a 321-residue protein from Saccharomyces cerevisiae (strain ATCC 204508 / S288c). This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q03290.
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The mean pLDDT of this model is 75.0 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 1% |
| 70 to 90 | Confident: backbone generally right | 77% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Acts as a component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro
Component of the transcription factor IIH (TFIIH) holo but not the TFIIH core complex. Component of a complex consisting of KIN28, CCL1 and TFB3; the KIN28-CCL1 dimer is known as the TFIIK complex
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7O4J | EM | 2.9 Å | 3=1-321 |
| 7ML0 | EM | 3.0 Å | 3=1-321 |
| 8CEN | EM | 3.0 Å | 3=1-321 |
| 7ML4 | EM | 3.1 Å | 3=1-321 |
| 7ZS9 | EM | 3.1 Å | 3=1-321 |
| 7O4I | EM | 3.2 Å | 3=1-321 |
| 7O75 | EM | 3.2 Å | 3=1-321 |
| 7ML2 | EM | 3.4 Å | 3=1-321 |
| 7O4L | EM | 3.4 Å | 3=1-321 |
| 7O72 | EM | 3.4 Å | 3=1-321 |
| 7O73 | EM | 3.4 Å | 3=1-321 |
| 7KUE | EM | 3.5 Å | C=1-321 |
| 7O4K | EM | 3.6 Å | 3=1-321 |
| 8CEO | EM | 3.6 Å | 3=1-321 |
| 6XI8 | EM | 3.64 Å | C=259-321 |
| 7ML1 | EM | 4.0 Å | 3=1-321 |
| 7ZSA | EM | 4.0 Å | 3=1-321 |
| 5OQJ | EM | 4.7 Å | 3=1-321 |
| 5OQM | EM | 5.8 Å | 3=1-321 |
| 7ZSB | EM | 6.6 Å | 3=1-321 |
Showing 20 of 22 experimental structures (best resolution first).
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