3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) is a 736-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q07343.
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The mean pLDDT of this model is 70.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 11% |
| 50 to 70 | Low: treat with caution | 4% |
| Below 50 | Very low: often disordered regions | 38% |
What pLDDT means and how to read it
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:15260978). May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents
Interacts with DISC1
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4KP6 | X-ray | 1.5 Å | A=324-659 |
| 2CHM | X-ray | 1.6 Å | A=451-476 |
| 5OHJ | X-ray | 1.6 Å | A/B=241-659 |
| 3FRG | X-ray | 1.7 Å | A=324-675 |
| 6BOJ | X-ray | 1.7 Å | A/B/C/D=663-673 |
| 3D3P | X-ray | 1.75 Å | A=324-675 |
| 3GWT | X-ray | 1.75 Å | A=324-675 |
| 1F0J | X-ray | 1.77 Å | A/B=324-700 |
| 3HC8 | X-ray | 1.79 Å | A=451-474 |
| 3HDZ | X-ray | 1.8 Å | A=451-474 |
| 5K6J | X-ray | 1.86 Å | A=334-656 |
| 8OEG | X-ray | 1.89 Å | A=241-659 |
| 4MYQ | X-ray | 1.9 Å | A=324-691 |
| 1XM6 | X-ray | 1.92 Å | A/B=323-700 |
| 2QYL | X-ray | 1.95 Å | A=324-659 |
| 3O0J | X-ray | 1.95 Å | A=334-656 |
| 1RO6 | X-ray | 2.0 Å | A/B=324-700 |
| 1ROR | X-ray | 2.0 Å | A/B=324-700 |
| 3O57 | X-ray | 2.0 Å | A=324-675 |
| 1XLZ | X-ray | 2.06 Å | A/B=323-700 |
Showing 20 of 42 experimental structures (best resolution first).
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