Forkhead box protein O1 (FOXO1) is a 655-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q12778.
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The mean pLDDT of this model is 51.0 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 4% |
| 50 to 70 | Low: treat with caution | 18% |
| Below 50 | Very low: often disordered regions | 68% |
What pLDDT means and how to read it
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose…
Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-256 leading to its nuclear import. Interacts (acetylated form) with PPARG. Interacts with XBP1 isoform 2; this interaction is…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8A62 | X-ray | 1.6 Å | B=20-29 |
| 8A65 | X-ray | 1.6 Å | B=21-28 |
| 6QZS | X-ray | 1.9 Å | C/P=251-262 |
| 3CO6 | X-ray | 2.1 Å | C=151-249 |
| 4LG0 | X-ray | 2.19 Å | A=143-270 |
| 3COA | X-ray | 2.2 Å | C/F=151-266 |
| 6QZR | X-ray | 2.3 Å | J/M/N/O/P/R/T/U=19-29 |
| 5DUI | X-ray | 2.31 Å | A/B=151-259 |
| 3CO7 | X-ray | 2.91 Å | C/F=151-266 |
| 6LBI | X-ray | 3.07 Å | C/D/G/H/K/L=151-265 |
| 6QVW | NMR | A=159-272 |
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