A-kinase anchor protein 13 (AKAP13) is a 179-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q12802.
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The mean pLDDT of this model is 80.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 25% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 13% |
What pLDDT means and how to read it
Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling…
Interacts with the cAMP-dependent protein kinase (PKA) holoenzyme and with the regulatory subunit PRKAR2A (PubMed:11285229, PubMed:11546812, PubMed:15229649, PubMed:1618839, PubMed:21102438). Interacts with RHOA (PubMed:11546812, PubMed:17537920, PubMed:24993829, PubMed:25186459). Also interacts with RHOB and RHOC (PubMed:11546812). Identified in a ternary complex with RHOA and PRKAR2A…
Cytoplasm, cytosol, Cytoplasm, Cytoplasm, cell cortex, Nucleus, Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6BCA | X-ray | 2.0 Å | A/B=2193-2333 |
| 4D0N | X-ray | 2.1 Å | B=1968-2338 |
| 4D0O | X-ray | 2.75 Å | A/B=1972-2207 |
| 2DRN | NMR | C=1246-1268 | |
| 2LG1 | NMR | A=2164-2346 |
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