SWI/SNF-related matrix-associated actin-dependent regulator of chromatin… (SMARCB1) is a 385-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q12824.
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The mean pLDDT of this model is 80.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 52% |
| 70 to 90 | Confident: backbone generally right | 26% |
| 50 to 70 | Low: treat with caution | 12% |
| Below 50 | Very low: often disordered regions | 11% |
What pLDDT means and how to read it
Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural…
Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5GJK | X-ray | 2.05 Å | B=183-249 |
| 5L7A | X-ray | 2.1 Å | A/B/C/D=184-252 |
| 6KZ7 | X-ray | 2.28 Å | B/D=171-252 |
| 6KAG | X-ray | 2.6 Å | A=169-385 |
| 6LTH | EM | 3.0 Å | M=1-385 |
| 7VDV | EM | 3.4 Å | V=1-385 |
| 9RL4 | EM | 3.5 Å | M=1-385 |
| 6LTJ | EM | 3.7 Å | M=1-113, M=172-385 |
| 9RN2 | EM | 4.1 Å | M=1-385 |
| 9RMC | EM | 4.2 Å | M=1-385 |
| 7Y8R | EM | 4.4 Å | M=1-385 |
| 9RN1 | EM | 5.9 Å | M=1-385 |
| 5AJ1 | NMR | A=2-113 | |
| 5L7B | NMR | A=184-258 | |
| 6AX5 | NMR | A=183-265 | |
| 6LZP | NMR | A=171-258 | |
| 6UCH | NMR | A=351-385 |
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