Splicing factor 3A subunit 3 (SF3A3) is a 501-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q12874.
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The mean pLDDT of this model is 86.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 54% |
| 70 to 90 | Confident: backbone generally right | 35% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 3% |
What pLDDT means and how to read it
Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310, PubMed:8022796). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A3 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and…
Component of the 17S U2 SnRNP complex, a ribonucleoprotein complex that contains small nuclear RNA (snRNA) U2 and a number of specific proteins (PubMed:21349847, PubMed:32494006, PubMed:34822310, PubMed:36797247). Part of the SF3A subcomplex of the 17S U2 SnRNP complex which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62 and SF3A1/SAP114 (PubMed:10882114, PubMed:11533230,…
Nucleus speckle, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7Q4O | EM | 2.2 Å | 9=1-501 |
| 7Q4P | EM | 2.2 Å | 9=1-501 |
| 7Q3L | EM | 2.3 Å | 9=1-501 |
| 7EVO | EM | 2.5 Å | C=1-501 |
| 8H6L | EM | 2.6 Å | 2F=1-501 |
| 8H6K | EM | 2.7 Å | 2F=1-501 |
| 8HK1 | EM | 2.7 Å | C=1-501 |
| 7VPX | EM | 3.0 Å | C=1-501 |
| 8I0R | EM | 3.0 Å | w=1-501 |
| 8I0T | EM | 3.0 Å | w=1-501 |
| 7ONB | EM | 3.1 Å | N=1-501 |
| 7QTT | EM | 3.1 Å | J=1-501 |
| 8H6E | EM | 3.2 Å | 2F=1-501 |
| 8H6J | EM | 3.25 Å | 2F=1-501 |
| 9ZE2 | EM | 3.26 Å | A3=1-501 |
| 6QX9 | EM | 3.28 Å | A3=1-501 |
| 8I0U | EM | 3.3 Å | w=1-501 |
| 8I0P | EM | 3.4 Å | w=1-501 |
| 9ZEC | EM | 3.61 Å | A3=1-501 |
| 6AHD | EM | 3.8 Å | w=1-501 |
Showing 20 of 43 experimental structures (best resolution first).
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