Serine/threonine-protein kinase 4 (STK4) is a 487-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13043.
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The mean pLDDT of this model is 75.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its…
Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation. Interacts with and stabilizes SAV1. Interacts with RASSF1. Interacts with FOXO3. Interacts with RASSF2 (via SARAH domain). Interacts with AR, PKB/AKT1, TNNI3 and SIRT1. Interacts with DLG5 (via PDZ domain 3). Interacts with MARK3 in the presence of DLG5 (PubMed:28087714). Interacts with SCRIB in…
Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8PAV | X-ray | 1.9 Å | A/B=1-311 |
| 4NR2 | X-ray | 2.0 Å | A/B/C/D/E/F/G/H=432-480 |
| 8A5J | X-ray | 2.12 Å | A/B=28-309 |
| 8PAW | X-ray | 2.14 Å | A/B=1-311 |
| 3COM | X-ray | 2.2 Å | A/B=2-311 |
| 4OH8 | X-ray | 2.28 Å | A=432-480 |
| 5TWG | X-ray | 2.3 Å | E=343-356 |
| 9VX3 | X-ray | 2.39 Å | A/D=431-480, B/E=398-480 |
| 5TWH | X-ray | 2.5 Å | E=358-374 |
| 7CEA | X-ray | 2.55 Å | A=431-480, B=414-480 |
| 6YAT | X-ray | 2.58 Å | A/B=1-311 |
| 9IIC | X-ray | 2.78 Å | A/B=11-311 |
| 7CEB | X-ray | 2.89 Å | C=431-480, D=412-480 |
| 8JG5 | EM | 3.04 Å | C/E=431-480, D/F=340-480 |
| 7CEC | EM | 3.9 Å | F/H=431-480, G=412-480, I=414-480 |
| 2JO8 | NMR | A/B=432-480 |
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