Serine/threonine-protein kinase 3 (STK3) is a 491-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13188.
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The mean pLDDT of this model is 76.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 50% |
| 70 to 90 | Confident: backbone generally right | 20% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 25% |
What pLDDT means and how to read it
Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation (PubMed:11278283, PubMed:8566796, PubMed:8816758). Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ…
Homodimer; mediated via the coiled-coil region. Interacts with NORE1, which inhibits autoactivation (By similarity). Interacts with and stabilizes SAV1 (PubMed:15688006, PubMed:16930133, PubMed:28087714, PubMed:29063833). Interacts with RAF1, which prevents dimerization and phosphorylation. Interacts with RASSF1. Interacts (via SARAH domain) with isoform 1 of NEK2. Interacts with ESR1 only in…
Cytoplasm, Nucleus, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4L0N | X-ray | 1.4 Å | A/B/C/D/E/F/G/H/I/J=436-484 |
| 4HKD | X-ray | 1.5 Å | A/B/C/D=436-484 |
| 6AR2 | X-ray | 1.55 Å | C/D=373-382 |
| 4OH9 | X-ray | 1.7 Å | A/B=436-484 |
| 8A66 | X-ray | 1.9 Å | A/B=16-312 |
| 3WWS | X-ray | 2.01 Å | A/B/C/D=436-484 |
| 4LG4 | X-ray | 2.42 Å | A/B/C/D/E/F=16-313 |
| 5DH3 | X-ray | 2.47 Å | A/B=15-313 |
| 5BRM | X-ray | 2.65 Å | G/H/I/J/K/L/M/N/O=371-401 |
| 6AO5 | X-ray | 2.96 Å | A=16-491 |
| 4LGD | X-ray | 3.05 Å | A/B/C/D=9-491 |
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