Protein unc-119 homolog A (UNC119) is a 240-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13432.
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The mean pLDDT of this model is 77.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 5% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid-binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the…
Interacts with CABP4; in the absence of calcium (By similarity). Interacts with DNM1; leading to a decrease of DNM1 GTPase activity (By similarity). May interact with GTP-bound ARL1. Interacts with ARL2 and ARL3 (GTP-bound forms); this promotes the release of myyristoylated cargo proteins (PubMed:22960633, PubMed:30945270). Found in a complex with ARL3, RP2 and UNC119; RP2 induces hydrolysis of…
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasm, cytoskeleton, spindle pole, Cytoplasm, cytoskeleton, spindle
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3GQQ | X-ray | 1.95 Å | A/B/C/D/E/F=56-240 |
| 3RBQ | X-ray | 2.0 Å | A/B/C/D/E/F=56-240 |
| 6H6A | X-ray | 2.0 Å | D/G/J=59-240 |
| 4GOJ | X-ray | 2.1 Å | C/D=1-240 |
| 5L7K | X-ray | 2.1 Å | A/G=58-237 |
| 9GKG | X-ray | 2.21 Å | A/B/C/D/E/K=59-240 |
| 7UMO | X-ray | 2.3 Å | A/B/C/D/E/F=57-240 |
| 9NEM | X-ray | 2.49 Å | A/B/C/D/E/F=57-240 |
| 4GOK | X-ray | 2.6 Å | C/G=1-240 |
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