Mucosal addressin cell adhesion molecule 1 (MADCAM1) is a 382-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q13477.
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The mean pLDDT of this model is 74.6 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 44% |
| 70 to 90 | Confident: backbone generally right | 16% |
| 50 to 70 | Low: treat with caution | 17% |
| Below 50 | Very low: often disordered regions | 24% |
What pLDDT means and how to read it
Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding
Homodimer
Membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4HBQ | X-ray | 1.4 Å | A/B=23-171, A/B=180-224 |
| 4HD9 | X-ray | 1.7 Å | A=23-225 |
| 1GSM | X-ray | 1.9 Å | A=19-224 |
| 1BQS | X-ray | 2.2 Å | A=23-231 |
| 4HCR | X-ray | 2.3 Å | A/B=23-225 |
| 4HC1 | X-ray | 2.87 Å | A/B=23-171, A/B=180-224 |
| 9P95 | EM | 3.05 Å | C=1-317 |
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