Guanine nucleotide-binding protein subunit alpha-13 (GNA13) is a 377-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14344.
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The mean pLDDT of this model is 91.4 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 81% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 5% |
What pLDDT means and how to read it
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16705036, PubMed:16787920, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:12515866, PubMed:15240885). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16705036, PubMed:16787920, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in a process independent from Rho…
G proteins are composed of 3 units; alpha, beta and gamma (PubMed:12399457). The alpha chain contains the guanine nucleotide binding site (By similarity). Interacts with UBXD5 (PubMed:16202387). Interacts with HAX1 (PubMed:15339924). Interacts (in GTP-bound form) with PPP5C (via TPR repeats); activates PPP5C phosphatase activity and translocates PPP5C to the cell membrane. Interacts with RGS22…
Cell membrane, Melanosome, Cytoplasm, Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8IKL | EM | 2.33 Å | A=17-29, A=31-56, A=59-250, A=252-377 |
| 9GE2 | EM | 2.51 Å | A=17-73, A=203-377 |
| 7SF8 | EM | 2.7 Å | B=17-377 |
| 8ZX4 | EM | 2.85 Å | A=17-377 |
| 9GE3 | EM | 2.87 Å | A=17-73, A=203-377 |
| 7SF7 | EM | 2.9 Å | B=17-377 |
| 9E51 | EM | 2.9 Å | B=203-377 |
| 9ECJ | EM | 2.9 Å | C=17-377 |
| 9IY8 | EM | 3.01 Å | A=17-377 |
| 8ZX5 | EM | 3.03 Å | A=17-377 |
| 9IZH | EM | 3.04 Å | A=165-377 |
| 8KGG | EM | 3.06 Å | A=204-377 |
| 7YDH | EM | 3.1 Å | A=17-377 |
| 7T6B | EM | 3.19 Å | A=48-377 |
| 8H8J | EM | 3.2 Å | A=34-377 |
| 9JHP | EM | 3.35 Å | A=31-72, A=203-377 |
| 9V0U | EM | 3.51 Å | A=31-73, A=203-377 |
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