Metabotropic glutamate receptor 2 (GRM2) is a 872-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14416.
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The mean pLDDT of this model is 85.7 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 30% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization
Forms heterodimers with GRM3 or GRM4 (PubMed:37286794). Interacts with TAMALIN (By similarity). Interacts with HTR2A
Cell membrane, Synapse, Cell projection, dendrite
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 4XAQ | X-ray | 2.21 Å | A/B=2-493 |
| 4XAS | X-ray | 2.35 Å | A/B=2-493 |
| 7EPE | X-ray | 2.5 Å | A=556-663, A=671-845 |
| 5CNJ | X-ray | 2.65 Å | A/B=2-493 |
| 5CNI | X-ray | 2.69 Å | A/B=2-493 |
| 7EPF | X-ray | 2.7 Å | A=556-663, A=671-845 |
| 5KZN | X-ray | 2.8 Å | A=1-564 |
| 5KZQ | X-ray | 2.8 Å | A=1-564 |
| 8JCU | EM | 2.8 Å | 2=19-872 |
| 8JD2 | EM | 2.8 Å | 2=19-872 |
| 8JCY | EM | 2.9 Å | 2=19-872 |
| 8JD4 | EM | 2.9 Å | 2=19-872 |
| 8JCW | EM | 3.0 Å | 2=19-872 |
| 8JCX | EM | 3.0 Å | 2=19-872 |
| 8JCZ | EM | 3.0 Å | 2=19-872 |
| 7EPB | EM | 3.1 Å | A/B=19-825 |
| 7MTS | EM | 3.2 Å | A/B=18-872 |
| 7MTR | EM | 3.3 Å | A/B=18-872 |
| 8JD0 | EM | 3.3 Å | 2=19-872 |
| 8JD3 | EM | 3.3 Å | 2=19-872 |
Showing 20 of 31 experimental structures (best resolution first).
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