Metabotropic Glutamate Receptor in complex with antagonist (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid. Determined by X-ray diffraction at 2.8 Å resolution. Released 28 Dec 2016.
Explore 5KZQ in 3D Show helices and sheets RCSB PDB PDBe
5KZQ contains 23 α-helices and 24 β-strands across 1 chain. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| β-strand | 26-28 | 3 | 1 |
| β-strand | 32-38 | 7 | 1 |
| β-strand | 41 | 1 | 2 |
| β-strand | 53 | 1 | 2 |
| α-helix | 59-74 | 16 | |
| α-helix | 82-83 | 2 | |
| β-strand | 84-90 | 7 | 1 |
| α-helix | 95-107 | 13 | |
| β-strand | 136-141 | 6 | 1 |
| α-helix | 145-155 | 11 | |
| α-helix | 156-158 | 3 | |
| β-strand | 162-164 | 3 | 1 |
| α-helix | 170-173 | 4 | |
| β-strand | 181-183 | 3 | 1 |
| α-helix | 186-187 | 2 | |
| α-helix | 189-202 | 14 | |
| β-strand | 206-212 | 7 | 3 |
| α-helix | 215-229 | 15 | |
| β-strand | 234-241 | 8 | 3 |
| α-helix | 247-258 | 12 | |
| β-strand | 265-269 | 5 | 3 |
| α-helix | 272-284 | 13 | |
| β-strand | 290-293 | 4 | 3 |
| α-helix | 308-311 | 4 | |
| β-strand | 315-319 | 5 | 3 |
| α-helix | 323-324 | 2 | |
| α-helix | 327-332 | 6 | |
| α-helix | 345-352 | 8 | |
| α-helix | 371-372 | 2 | |
| α-helix | 378-399 | 22 | |
| α-helix | 408-410 | 3 | |
| α-helix | 415-418 | 4 | |
| α-helix | 419-423 | 5 | |
| β-strand | 427-429 | 3 | 4 |
| β-strand | 440-442 | 3 | 4 |
| β-strand | 443 | 1 | 5 |
| β-strand | 449 | 1 | 5 |
| β-strand | 453-460 | 8 | 3 |
| β-strand | 466-474 | 9 | 3 |
| β-strand | 478-480 | 3 | 3 |
| α-helix | 482-484 | 3 | |
| α-helix | 502-504 | 3 | |
| β-strand | 508-512 | 5 | 6 |
| β-strand | 520-524 | 5 | 6 |
| α-helix | 525-526 | 2 | |
| β-strand | 529-531 | 3 | 7 |
| β-strand | 537-539 | 3 | 7 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 2 | A | protein | 570 | Homo sapiens | Q14416 (AlphaFold model) |
>5KZQ_1 Metabotropic glutamate receptor 2 (chains A) MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQ RLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHI CPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDY FARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEK VGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGAL ESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQR DCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTL DTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADC GLGYWPNASLTGCFELPQEYIREGHHHHHH
| ID | Name | Formula | Copies |
|---|---|---|---|
| NAG | 2-acetamido-2-deoxy-beta-D-glucopyranose | C8 H15 N O6 | 1 |
| 6YS | (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sul… | C15 H15 F2 N O5 S | 1 |
Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity. Chappell, M.D., Li, R., Smith, S.C. et al. J Med Chem (2016) 59:10974-10993. PubMed
Other PDB entries of the same protein (UniProt Q14416 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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