Metabotropic glutamate receptor 3 (GRM3) is a 879-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14832.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 85.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 59% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 7% |
| Below 50 | Very low: often disordered regions | 6% |
What pLDDT means and how to read it
G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity
Interacts with TAMALIN
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3SM9 | X-ray | 2.26 Å | A=26-504 |
| 4XAR | X-ray | 2.26 Å | A=2-508 |
| 8JCU | EM | 2.8 Å | 3=23-879 |
| 8JD2 | EM | 2.8 Å | 3=23-879 |
| 6B7H | X-ray | 2.82 Å | A=2-507 |
| 5CNM | X-ray | 2.84 Å | A=2-507 |
| 8JCY | EM | 2.9 Å | 3=23-879 |
| 8JCW | EM | 3.0 Å | 3=23-879 |
| 8JCX | EM | 3.0 Å | 3=23-879 |
| 8JCZ | EM | 3.0 Å | 3=23-879 |
| 5CNK | X-ray | 3.15 Å | A/B/C=2-507 |
| 8JD0 | EM | 3.3 Å | 3=23-879 |
| 8JD3 | EM | 3.3 Å | 3=23-879 |
| 8JCV | EM | 3.4 Å | 3=23-879 |
| 7WIH | EM | 3.68 Å | A/B=23-879 |
| 8JD1 | EM | 3.7 Å | 3=23-879 |
| 9II2 | EM | 3.7 Å | B/R=1-879 |
| 7WI6 | EM | 3.71 Å | A/B=23-879 |
| 9II3 | EM | 3.9 Å | B/R=1-879 |
| 7WI8 | EM | 4.17 Å | A/B=23-879 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.