Hepatic sodium/bile acid cotransporter (SLC10A1) is a 349-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q14973.
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The mean pLDDT of this model is 83.5 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 58% |
| 70 to 90 | Confident: backbone generally right | 24% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It is strictly dependent on the extracellular presence of sodium (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter…
(Microbial infection) Interacts with the myristoylated pre-S1 domain of hepatitis B virus large envelope protein; myristoylation is essential for this interaction
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7ZYI | EM | 2.88 Å | A=1-349 |
| 8HRX | EM | 2.89 Å | A=1-319 |
| 8HRY | EM | 3.11 Å | A=1-319 |
| 9QZQ | EM | 3.11 Å | A=1-349 |
| 7FCI | EM | 3.3 Å | A=1-349 |
| 7PQQ | EM | 3.3 Å | A=3-328 |
| 7VAG | EM | 3.32 Å | A=1-319 |
| 7WSI | EM | 3.32 Å | A=1-319 |
| 7VAD | EM | 3.41 Å | A=1-319 |
| 8RQF | EM | 3.41 Å | A=1-349 |
| 7PQG | EM | 3.7 Å | A=3-328 |
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