Nuclear receptor coactivator 2 (NCOA2) is a 1464-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15596.
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The mean pLDDT of this model is 47.6 (very low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 10% |
| 70 to 90 | Confident: backbone generally right | 10% |
| 50 to 70 | Low: treat with caution | 9% |
| Below 50 | Very low: often disordered regions | 72% |
What pLDDT means and how to read it
Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:23508108, PubMed:8670870, PubMed:9430642, PubMed:22504882, PubMed:26553876). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:23508108, PubMed:8670870, PubMed:9430642). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:23508108, PubMed:8670870, PubMed:9430642). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:23508108, PubMed:8670870, PubMed:9430642). Involved in the positive regulation of the transcriptional activity of the…
Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP (PubMed:11971985, PubMed:9430642). Present in a complex containing CARM1 and EP300/P300. Interacts (via C-terminus) with CREBBP (PubMed:11971985, PubMed:9430642). Interacts (via LXXLL 1, 2 and 3 motifs) with RORA (via AF-2 motif) (PubMed:10478845). Interacts (via LXXLL 1, 2 and 3 motifs) with RORC (via AF-2 motif). Interacts…
Nucleus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 3UP3 | X-ray | 1.25 Å | P=741-754 |
| 7NFB | X-ray | 1.33 Å | C/D=686-699 |
| 7NEL | X-ray | 1.45 Å | C/D=686-699 |
| 9QX6 | X-ray | 1.46 Å | B=687-696 |
| 5DXE | X-ray | 1.5 Å | C/D=687-697 |
| 6LB4 | X-ray | 1.5 Å | B=686-698 |
| 7A77 | X-ray | 1.5 Å | B=686-699 |
| 5APH | X-ray | 1.54 Å | C=686-697 |
| 6R7K | X-ray | 1.54 Å | C=684-698 |
| 7RAF | X-ray | 1.55 Å | D=742-753 |
| 7RKE | X-ray | 1.55 Å | C/D=687-696 |
| 7PDQ | X-ray | 1.58 Å | B=686-698 |
| 3UP0 | X-ray | 1.6 Å | P/Q=740-753 |
| 5KCT | X-ray | 1.6 Å | C/D=686-699 |
| 7OFK | X-ray | 1.61 Å | C=684-698 |
| 6HL1 | X-ray | 1.65 Å | B=740-752 |
| 9RMR | X-ray | 1.65 Å | B=687-696 |
| 1T65 | X-ray | 1.66 Å | B=686-698 |
| 6KKB | X-ray | 1.7 Å | D=741-751 |
| 6VC2 | X-ray | 1.7 Å | C=740-754 |
Showing 20 of 381 experimental structures (best resolution first).
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