Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) is a 312-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15628.
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The mean pLDDT of this model is 83.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 60% |
| 70 to 90 | Confident: backbone generally right | 23% |
| 50 to 70 | Low: treat with caution | 5% |
| Below 50 | Very low: often disordered regions | 12% |
What pLDDT means and how to read it
Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD (PubMed:23955153, PubMed:7758105, PubMed:8612133). Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B (PubMed:7758105, PubMed:8612133). The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity)
Stimulation of TNF receptor TNFRSF1A leads to the formation of two distinct signaling complexes (PubMed:14585990, PubMed:21307340, PubMed:7758105, PubMed:8612133). Plasma membrane-bound complex I is composed of TNFRSF1A, TRADD, RIPK1, TRAF2 and BIRC2/c-IAP1 or BIRC3 which interacts with CHUCK/IKK-alpha, IKBKB/IKK-beta and IKBKG/IKK-gamma promoting cell survival (PubMed:14585990, PubMed:21307340,…
Nucleus, Cytoplasm, Cytoplasm, cytoskeleton
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6AC0 | X-ray | 1.45 Å | A=195-312 |
| 1F3V | X-ray | 2.0 Å | A=1-179 |
| 9VGD | EM | 3.3 Å | A/B/C/E/F/H/I/J/K/M/N/Q/R/S/T/V/W/Y/Z/b/c/e/f/g/h/j/k/l=199-312 |
| 9VIN | EM | 3.41 Å | E/F/N/V/W=199-312 |
| 1F2H | NMR | A=1-169 | |
| 5XME | NMR | A=199-312 | |
| 7CSQ | NMR | B=199-312 |
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