ELAV-like protein 1 (ELAVL1) is a 326-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q15717.
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The mean pLDDT of this model is 79.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 57% |
| 70 to 90 | Confident: backbone generally right | 19% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the…
Monomer and homodimer (in vitro) (PubMed:17632515, PubMed:20219472). Interacts with ANP32A (PubMed:11729309). Interacts with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1…
Cytoplasm, Nucleus, Cytoplasm, Stress granule, Cytoplasm, P-body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6GD3 | X-ray | 1.35 Å | A/B/C=243-326 |
| 4FXV | X-ray | 1.9 Å | A/B/C/D=20-99 |
| 6GC5 | X-ray | 1.9 Å | A/B/C/D=241-326 |
| 6GD2 | X-ray | 1.9 Å | A/B/C=243-326 |
| 3HI9 | X-ray | 2.0 Å | A/B/C/D=18-99 |
| 4ED5 | X-ray | 2.0 Å | A/B=18-186 |
| 6G2K | X-ray | 2.01 Å | A/B/C=243-326 |
| 6GD1 | X-ray | 2.01 Å | A/B=243-326 |
| 4EGL | X-ray | 2.9 Å | A=18-186 |
| 9W2F | EM | 3.4 Å | C=15-99 |
| 5SZW | NMR | A=1-99 |
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