Bcl-2-related protein A1 (BCL2A1) is a 175-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q16548.
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The mean pLDDT of this model is 87.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 63% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 15% |
| Below 50 | Very low: often disordered regions | 0% |
What pLDDT means and how to read it
Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). Can inhibit apoptosis induced by serum starvation in the mammary epithelial cell line HC11 (By similarity)
Interacts directly with BAK1, BID, BMF and BBC3 (By similarity). Interacts directly with BCL2L11/BIM. Interacts with BAX isoform Sigma. Interacts directly with PMAIP1. Interacts with RTL10/BOP. Interacts with ING4 (By similarity). Interacts with UBQLN4 (PubMed:34245648)
Cytoplasm
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 9GIR | X-ray | 1.07 Å | A=1-151 |
| 9GIT | X-ray | 1.15 Å | A=1-151 |
| 5UUK | X-ray | 1.2 Å | A=1-151 |
| 5UUL | X-ray | 1.33 Å | A=1-151 |
| 9GIS | X-ray | 1.39 Å | A/B=1-151 |
| 9GIQ | X-ray | 1.42 Å | A=1-151 |
| 9S6M | X-ray | 1.43 Å | A/B=1-151 |
| 9GIP | X-ray | 1.46 Å | A=1-151 |
| 6E3I | X-ray | 1.48 Å | A=1-151 |
| 6E3J | X-ray | 1.48 Å | A=1-151 |
| 9EW8 | X-ray | 1.49 Å | A=1-151 |
| 9FKY | X-ray | 1.56 Å | A/B=1-151 |
| 6MBB | X-ray | 1.59 Å | A=1-151 |
| 9FKZ | X-ray | 1.68 Å | A=1-151 |
| 5WHI | X-ray | 1.69 Å | A=1-151 |
| 5UUP | X-ray | 1.73 Å | A=1-151 |
| 6VO4 | X-ray | 1.74 Å | A=1-151 |
| 6MBC | X-ray | 1.75 Å | A=1-151 |
| 8RPO | X-ray | 1.79 Å | A=1-151 |
| 4ZEQ | X-ray | 1.8 Å | A=1-151 |
Showing 20 of 26 experimental structures (best resolution first).
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