Nucleoside diphosphate kinase homolog 7 (NME7) is a 377-residue protein from Bos taurus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5E9Y9.
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The mean pLDDT of this model is 91.8 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 75% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 2% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner. May maintain primary cilium assembly…
Component of sperm flagellar doublet microtubules (PubMed:37327785). Component of the gamma-tubulin ring complex (By similarity)
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Nucleus, Cytoplasm, Cytoplasm, cytoskeleton, spindle, Cytoplasm, cytoskeleton, cilium axoneme, Cytoplasm, cytoskeleton, flagellum axoneme, Cell projection, cilium, Cytoplasm, cytoskeleton, cilium basal body
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 7RRO | EM | 3.4 Å | 5/6=1-377 |
| 9CPB | EM | 3.52 Å | 4I/4J=1-377 |
| 8OTZ | EM | 3.6 Å | AV/AW=1-377 |
| 9FQR | EM | 5.0 Å | AV/AW/Ah/Kd/Ke=1-377 |
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