Free fatty acid receptor 4 (FFAR4) is a 361-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5NUL3.
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The mean pLDDT of this model is 79.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 47% |
| 70 to 90 | Confident: backbone generally right | 28% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 16% |
What pLDDT means and how to read it
G protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G protein and beta-arrestin pathways (PubMed:22282525, PubMed:22343897, PubMed:24742677, PubMed:24817122, PubMed:27852822). LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs) (PubMed:22282525, PubMed:22343897, PubMed:24742677, PubMed:27852822). After LCFAs binding,…
Interacts (via C-terminus) with ARRB2 following LCFAs stimulation
Cell membrane, Endosome membrane, Lysosome membrane, Cell projection, cilium membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8G59 | EM | 2.64 Å | R=1-361 |
| 8ID6 | EM | 2.8 Å | R=1-361 |
| 8IYS | EM | 2.95 Å | R=1-361 |
| 8ID8 | EM | 3.0 Å | R=1-361 |
| 8ID9 | EM | 3.0 Å | R=1-361 |
| 8H4I | EM | 3.06 Å | R=1-361 |
| 8T3O | EM | 3.06 Å | R=22-328 |
| 8H4L | EM | 3.07 Å | R=1-361 |
| 8H4K | EM | 3.1 Å | R=1-361 |
| 8ID3 | EM | 3.1 Å | R=1-361 |
| 8ID4 | EM | 3.1 Å | R=1-361 |
| 8T3Q | EM | 3.14 Å | R=22-329 |
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