Protein-cysteine N-palmitoyltransferase HHAT (HHAT) is a 493-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q5VTY9.
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The mean pLDDT of this model is 92.9 (very high overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 86% |
| 70 to 90 | Confident: backbone generally right | 12% |
| 50 to 70 | Low: treat with caution | 1% |
| Below 50 | Very low: often disordered regions | 1% |
What pLDDT means and how to read it
Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of hedgehog (DHH, IHH or SHH) morphogens, promoting their maturation (PubMed:11486055, PubMed:18534984, PubMed:24784881, PubMed:31875564, PubMed:34112694, PubMed:34890564). Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where hedgehog palmitoylation occurs (PubMed:31875564, PubMed:34112694, PubMed:34890564). Required for hedgehog signaling during limb development (By similarity). Plays a role in proper testis cord formation and the differentiation of Leydig cells (PubMed:24784881)
Endoplasmic reticulum membrane, Golgi apparatus membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 6UJO | X-ray | 2.25 Å | C=68-76 |
| 6UJQ | X-ray | 2.55 Å | C=68-76 |
| 6UK4 | X-ray | 2.7 Å | C=68-76 |
| 7MHY | EM | 2.7 Å | A=1-493 |
| 7Q1U | EM | 2.7 Å | A=1-493 |
| 7URF | EM | 2.8 Å | A=1-493 |
| 6P64 | X-ray | 3.05 Å | C/H=68-76 |
| 6UK2 | X-ray | 3.14 Å | C=68-76 |
| 7MHZ | EM | 3.2 Å | A=1-493 |
| 7Q6Z | EM | 3.59 Å | A=1-493 |
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