Disks large homolog 1 (Dlg1) is a 911-residue protein from Rattus norvegicus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q62696.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 72.4 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 45% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 3% |
| Below 50 | Very low: often disordered regions | 30% |
What pLDDT means and how to read it
Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (By similarity)
Homotetramer (By similarity). Interacts (via guanylate kinase-like domain) with DLGAP1, DLGAP2, DLGAP3, DLGAP4 and MAP1A (PubMed:9115257, PubMed:9786987). Interacts (via guanylate kinase-like domain) with KIF13B (By similarity). May interact with HTR2A (By similarity). Interacts (via PDZ domains) with GRIA1 (PubMed:9677374). Interacts (via PDZ domains) with GRIN2A (PubMed:12933808). Interacts…
Cell membrane, Basolateral cell membrane, Endoplasmic reticulum membrane, Postsynaptic density, Synapse, Cell membrane, sarcolemma, Cell junction, Cytoplasm, Apical cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 2AWX | X-ray | 1.8 Å | A/B=314-409 |
| 2AWW | X-ray | 2.21 Å | A/B=314-409 |
| 2I0L | X-ray | 2.31 Å | A/B=318-401 |
| 2G2L | X-ray | 2.35 Å | A/B=314-409 |
| 2AWU | X-ray | 2.44 Å | A/B=314-409 |
| 3UAT | X-ray | 2.7 Å | A=578-911 |
| 2I0I | X-ray | 2.8 Å | A/B/C=459-543 |
| 1RSO | NMR | A/C=4-63 | |
| 1ZOK | NMR | A=221-313 |
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