Adapter molecule crk (Crk) is a 304-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q64010.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 69.8 (low overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 2% |
| 70 to 90 | Confident: backbone generally right | 62% |
| 50 to 70 | Low: treat with caution | 13% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1
Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (By similarity). Within the complex, interacts with SH2D3C (via C-terminus), and BCAR1/CAS (By similarity). Found in a complex with ABL1, ABL2, CRK and UNC119; leading to the inhibition of CRK phosphorylation by ABL kinases (By similarity). Interacts with ABL1, C3G, DOCK3, DOCK5, MAP4K1, MAPK8 and SOS via its first SH3 domain.…
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1CKA | X-ray | 1.5 Å | A=134-190 |
| 5JN0 | X-ray | 1.68 Å | A=6-121 |
| 5L23 | X-ray | 1.77 Å | A=134-191 |
| 5IH2 | X-ray | 1.8 Å | A/B=134-191 |
| 1CKB | X-ray | 1.9 Å | A=134-190 |
| 1B07 | X-ray | 2.5 Å | A=134-190 |
| 1JU5 | NMR | B=217-228 | |
| 1M30 | NMR | A=134-191 | |
| 1M3A | NMR | A=135-191 | |
| 1M3B | NMR | A=134-191 | |
| 1M3C | NMR | A=132-191 | |
| 2GGR | NMR | A=230-304 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.