Guanine nucleotide exchange factor DBS (Mcf2l) is a 1149-residue protein from Mus musculus. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q64096.
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The mean pLDDT of this model is 75.3 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 49% |
| 70 to 90 | Confident: backbone generally right | 22% |
| 50 to 70 | Low: treat with caution | 6% |
| Below 50 | Very low: often disordered regions | 23% |
What pLDDT means and how to read it
Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (PubMed:11889037, PubMed:12006984, PubMed:17000758). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity)
Interacts with GTP-bound RAC1 (By similarity). Interacts with CDC42 (PubMed:11889037). Interacts with RHOA (PubMed:12006984). Interacts with CCPG1, which results in specific inhibition of its exchange activity toward RHOA, but does not affect its activity on CDC42 (PubMed:17000758)
Cytoplasm, Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 1KZ7 | X-ray | 2.4 Å | A/C=623-967 |
| 1KZG | X-ray | 2.6 Å | A/C=623-968 |
| 1LB1 | X-ray | 2.81 Å | A/C/E/G=623-967 |
| 1RJ2 | X-ray | 3.0 Å | A/D/G/J=623-968 |
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