Unconventional myosin-VIIb (MYO7B) is a 2116-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6PIF6.
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The mean pLDDT of this model is 77.8 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 18% |
| 70 to 90 | Confident: backbone generally right | 64% |
| 50 to 70 | Low: treat with caution | 8% |
| Below 50 | Very low: often disordered regions | 10% |
What pLDDT means and how to read it
Myosins are actin-based motor molecules with ATPase activity. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length (PubMed:24725409, PubMed:26812018, PubMed:32209652). May link the complex to the actin core bundle of microvilli
Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5 (PubMed:24725409, PubMed:26812018, PubMed:32209652). Interacts with CDHR2 (PubMed:24725409). Interacts with CDHR5 (PubMed:24725409). Interacts with USH1C (PubMed:24725409, PubMed:26812017, PubMed:26812018). Interacts with ANKS4B; requires initial interaction with…
Cytoplasm, cytoskeleton, Cell projection, microvillus
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 5XBF | X-ray | 1.8 Å | A=1601-2116 |
| 5MV8 | X-ray | 1.88 Å | A=1609-2116 |
| 5MV7 | X-ray | 2.44 Å | A=1605-2116 |
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