Structure of human Myosin 7b C-terminal MyTH4-FERM domain in complex with harmonin-a PDZ3 domain. Determined by X-ray diffraction at 1.88 Å resolution. Released 5 Jul 2017.
Explore 5MV8 in 3D Show helices and sheets RCSB PDB PDBe
5MV8 contains 33 α-helices and 22 β-strands across 2 chains. Residue ranges use author residue numbering, as in the PDB file, from PDBe. To see them in 3D, choose the Cartoon representation with Secondary structure coloring: helices, sheets and coils get different colors.
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 1605-1609 | 5 | |
| α-helix | 1612-1618 | 7 | |
| β-strand | 1619 | 1 | 1 |
| α-helix | 1620-1622 | 3 | |
| α-helix | 1648-1649 | 2 | |
| β-strand | 1654 | 1 | 1 |
| α-helix | 1655-1658 | 4 | |
| α-helix | 1663-1678 | 16 | |
| α-helix | 1689-1702 | 14 | |
| α-helix | 1704-1706 | 3 | |
| α-helix | 1707-1717 | 11 | |
| α-helix | 1724-1738 | 15 | |
| α-helix | 1742-1744 | 3 | |
| α-helix | 1748-1756 | 9 | |
| α-helix | 1764-1777 | 14 | |
| α-helix | 1786-1793 | 8 | |
| β-strand | 1799-1805 | 7 | 2 |
| β-strand | 1809-1815 | 7 | 2 |
| β-strand | 1820 | 1 | 3 |
| α-helix | 1821-1832 | 12 | |
| β-strand | 1840-1846 | 7 | 2 |
| β-strand | 1849-1852 | 4 | 2 |
| α-helix | 1853-1854 | 2 | |
| β-strand | 1858 | 1 | 3 |
| α-helix | 1859-1873 | 15 | |
| α-helix | 1883-1885 | 3 | |
| β-strand | 1886-1892 | 7 | 2 |
| α-helix | 1904-1906 | 3 | |
| α-helix | 1907-1911 | 5 | |
| α-helix | 1912-1920 | 9 | |
| α-helix | 1928-1943 | 16 | |
| α-helix | 1957-1959 | 3 | |
| α-helix | 1966-1968 | 3 | |
| α-helix | 1971-1982 | 12 | |
| α-helix | 1983-1985 | 3 | |
| α-helix | 1990-2001 | 12 | |
| β-strand | 2010-2016 | 7 | 4 |
| β-strand | 2025-2031 | 7 | 4 |
| β-strand | 2034-2038 | 5 | 4 |
| β-strand | 2045-2049 | 5 | 4 |
| β-strand | 2056-2059 | 4 | 4 |
| β-strand | 2063-2067 | 5 | 4 |
| β-strand | 2076-2080 | 5 | 4 |
| α-helix | 2084-2098 | 15 |
| Element | Residues | Length | Sheet |
|---|---|---|---|
| α-helix | 439-441 | 3 | |
| α-helix | 445-448 | 4 | |
| β-strand | 453-459 | 7 | 5 |
| β-strand | 466-471 | 6 | 5 |
| β-strand | 478-484 | 7 | 5 |
| α-helix | 500 | 1 | |
| β-strand | 501-505 | 5 | 5 |
| β-strand | 508-509 | 2 | 5 |
| α-helix | 515-527 | 13 | |
| β-strand | 532-538 | 7 | 5 |
| α-helix | 539-542 | 4 |
| Molecule | Chains | Type | Length | Organism | UniProt |
|---|---|---|---|---|---|
| Unconventional myosin-VIIb | A | protein | 527 | Homo sapiens | Q6PIF6 (AlphaFold model) |
| cDNA FLJ51329, highly similar to Harmonin | B | protein | 130 | Homo sapiens | Q9Y6N9 (AlphaFold model) |
>5MV8_1 Unconventional myosin-VIIb (chains A) MGSSHHHHHHHSSHHKEKLHTLEEFSYEFFRAPEKDMVSMAVLPLARARGHLWAYSCEPL RQPLLKRVHADVDLWNIACEIFVAILRYMGDYPSRQAWPTLELTDQIFTLALQHPALQDE VYCQILKQLTHNSNRHSEERGWQLLWLCTGLFPPSKGLLPHAQKFIDTRRGKLLAPDCSR RIQKVLRTGPRKQPPHEVEVEAAEQNVSRICHKIYFPNDTSEMLEVVANTRVRDVCDSIA TRLQLASWEGCSLFIKISDKVISQKEGDFFFDSLREVSDWVKKNKPQKEGAPVTLPYQVY FMRKLWLNISPGKDVNADTILHYHQELPKYLRGFHKCSREDAIHLAGLIYKAQFNNDRSQ LASVPKILRELVPENLTRLMSSEEWKKSILLAYDKHKDKTVEEAKVAFLKWICRWPTFGS AFFEVKQTSEPSYPDVILIAINRHGVLLIHPKTKDLLTTYPFTKISSWSSGSTYFHMALG SLGRGSRLLCETSLGYKMDDLLTSYVQQLLSAMNKQRGSKAPALAST
>5MV8_2 cDNA FLJ51329, highly similar to Harmonin (chains B) GAMGSQDFRKYEEGFDPYSMFTPEQIMGKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVS AVYERGAAERHGGIVKGDEIMAINGKIVTDYTLAEADAALQKAWNQGGDWIDLVVAVCPP KEYDDELTFF
| ID | Name | Formula | Copies |
|---|---|---|---|
| MG | Magnesium ion | Mg | 1 |
Water and common crystallization additives (GOL) are not listed.
Myosin 7 and its adaptors link cadherins to actin. Yu, I.M., Planelles-Herrero, V.J., Sourigues, Y. et al. Nat Commun (2017) 8:15864-15864. DOI 10.1038/ncomms15864 · PubMed
Other PDB entries of the same protein (UniProt Q6PIF6 (AlphaFold model), which also has an AlphaFold model), best resolution first:
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