Adhesion G-protein coupled receptor D1 (ADGRD1) is a 874-residue protein from Homo sapiens. This is its AlphaFold structure prediction, created 1 Aug 2025. UniProt accession: Q6QNK2.
Explore in 3D Color by confidence AlphaFold DB UniProt
The mean pLDDT of this model is 71.9 (confident overall). pLDDT is AlphaFold's per-residue confidence score from 0 to 100. In MolViewer, choose the B-factor color scheme to color the model by pLDDT, because AlphaFold stores it in the B-factor column.
| pLDDT band | Meaning | Share of residues |
|---|---|---|
| Above 90 | Very high: backbone and side chains are usually accurate | 19% |
| 70 to 90 | Confident: backbone generally right | 47% |
| 50 to 70 | Low: treat with caution | 14% |
| Below 50 | Very low: often disordered regions | 21% |
What pLDDT means and how to read it
Adhesion G protein-coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha-DHT receptor in muscle cells,…
Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked (By similarity) (PubMed:34022221, PubMed:35418678). Interacts with ESYT1; interaction takes place in absence of cytosolic calcium and inhibits the G protein-coupled receptor activity of ADGRD1…
Cell membrane
Compare the prediction with experimentally determined structures of the same protein:
| PDB ID | Method | Resolution | Chains and residues |
|---|---|---|---|
| 8X9T | EM | 2.75 Å | R=277-874 |
| 7WU2 | EM | 2.8 Å | R=545-827 |
| 8X9U | EM | 2.88 Å | R=277-874 |
| 9IV1 | EM | 2.98 Å | R=562-874 |
| 7EPT | EM | 3.0 Å | R=545-827 |
| 8X9S | EM | 3.49 Å | R=277-874 |
| 9V0U | EM | 3.51 Å | R=277-874 |
| 9IV2 | EM | 3.53 Å | R=277-874 |
MolViewer loads the AlphaFold model straight from AlphaFold DB into your browser. Show it as a cartoon, color by pLDDT, measure distances and angles, and load a PDB structure next to it to compare.